| |  Online-Ressource |
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| Verfasst von: | Xu, Zhen [VerfasserIn]  |
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| | Huang, Zhenhua [VerfasserIn] |
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| | Zhang, Yifan [VerfasserIn] |
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| | Sun, Haitao [VerfasserIn] |
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| | Hinz, Ulf [VerfasserIn] |
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| | Heger, Ulrike [VerfasserIn] |
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| | Loos, Martin [VerfasserIn] |
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| | Gonzalez, Frank J. [VerfasserIn] |
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| | Hackert, Thilo [VerfasserIn] |
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| | Bergmann, Frank [VerfasserIn] |
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| | Fortunato, Franco [VerfasserIn] |
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| Titel: | Farnesoid X receptor activation inhibits pancreatic carcinogenesis |
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| Verf.angabe: | Zhen Xu, Zhenhua Huang, Yifan Zhang, Haitao Sun, Ulf Hinz, Ulrike Heger, Martin Loos, Frank J. Gonzalez, Thilo Hackert, Frank Bergmann, Franco Fortunato |
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| E-Jahr: | 2023 |
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| Jahr: | 27 July 2023 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 28.11.2023 |
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| Titel Quelle: | Enthalten in: Biochimica et biophysica acta / Molecular basis of disease |
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| Ort Quelle: | Amsterdam : Elsevier, 1990 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 1869(2023), 7, Artikel-ID 166811, Seite 1-14 |
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| ISSN Quelle: | 1879-260X |
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| Abstract: | Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily that controls bile acid (BA) homeostasis, has also been proposed as a tumor suppressor for breast and liver cancer. However, its role in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis remains controversial. We recently found that FXR attenuates acinar cell autophagy in chronic pancreatitis resulting in reduced autophagy and promotion of pancreatic carcinogenesis. Feeding Kras-p48-Cre (KC) mice with the BA chenodeoxycholic acid (CDCA), an FXR agonist, attenuated pancreatic intraepithelial neoplasia (PanIN) progression, reduced cell proliferation, neoplastic cells and autophagic activity, and increased acinar cells, elevated pro-inflammatory cytokines and chemokines, with a compensatory increase in the anti-inflammatory response. Surprisingly, FXR-deficient KC mice did not show any response to CDCA, suggesting that CDCA attenuates PanIN progression and decelerate tumorigenesis in KC mice through activating pancreatic FXR. FXR is activated in pancreatic cancer cell lines in response to CDCA in vitro. FXR levels were highly increased in adjuvant and neoadjuvant PDAC tissue compared to healthy pancreatic tissue, indicating that FXR is expressed and potentially activated in human PDAC. These results suggest that BA exposure activates inflammation and suppresses autophagy in KC mice, resulting in reduced PanIN lesion progression. These data suggest that activation of pancreatic FXR has a protective role by reducing the growth of pre-cancerous PDAC lesions in response to CDCA and possibly other FXR agonists. |
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| DOI: | doi:10.1016/j.bbadis.2023.166811 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.bbadis.2023.166811 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0925443923001771 |
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| | DOI: https://doi.org/10.1016/j.bbadis.2023.166811 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Bile acid |
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| | Farnesoid X receptor |
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| | Pancreatic carcinogenesis |
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| | Pancreatic ductal adenocarcinoma |
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| K10plus-PPN: | 1871490286 |
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| Verknüpfungen: | → Zeitschrift |
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Farnesoid X receptor activation inhibits pancreatic carcinogenesis / Xu, Zhen [VerfasserIn]; 27 July 2023 (Online-Ressource)
