| |  Online-Ressource |
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| Verfasst von: | Stelzel, Christine [VerfasserIn]  |
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| | Basten, Ulrike [VerfasserIn] |
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| | Montag, Christian [VerfasserIn] |
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| | Reuter, Martin [VerfasserIn] |
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| | Fiebach, Christian [VerfasserIn] |
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| Titel: | Frontostriatal involvement in task switching depends on genetic differences in d2 receptor density |
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| Verf.angabe: | Christine Stelzel, Ulrike Basten, Christian Montag, Martin Reuter, and Christian J. Fiebach |
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| E-Jahr: | 2010 |
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| Jahr: | Aug. 24, 2010 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 28.11.2023 |
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| Titel Quelle: | Enthalten in: The journal of neuroscience |
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| Ort Quelle: | Washington, DC : Soc., 1981 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 30(2010), 42, Seite 14205-14212 |
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| ISSN Quelle: | 1529-2401 |
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| Abstract: | Recent studies suggest an association of dopamine D2 receptor (DRD2) availability with flexibility in reward-based learning. We extend these results by demonstrating an association of genetically based differences in DRD2 density with the ability to intentionally switch between nonrewarded tasks: noncarriers of the A1 allele of the DRD2/ANKK1-TaqIa polymorphism, associated with higher DRD2 density, show increased task-switching costs, increased prefrontal switching activity in the inferior frontal junction area, and increased functional connectivity in dorsal frontostriatal circuits, relative to A1 allele carriers. A DRD2 haplotype analysis in the same sample confirmed these results, indicating an association between high D2 density and increased task-switching effort. Our results provide evidence that converges with that from association studies relating increased D2 density to deficits in cognitive flexibility in schizophrenia. We suggest that individual differences in striatal D2 signaling in healthy humans modulate goal-directed gating to prefrontal cortex, thus leading to individual differences in switching intentionally to newly relevant behaviors. |
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| DOI: | doi:10.1523/JNEUROSCI.1062-10.2010 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
DOI: https://doi.org/10.1523/JNEUROSCI.1062-10.2010 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cognition |
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| | Corpus Striatum |
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| | DNA |
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| | Female |
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| | Haplotypes |
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| | Humans |
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| | Individuality |
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| | Magnetic Resonance Imaging |
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| | Male |
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| | Neural Pathways |
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| | Neuronal Plasticity |
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| | Polymorphism, Genetic |
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| | Prefrontal Cortex |
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| | Protein Serine-Threonine Kinases |
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| | Psychomotor Performance |
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| | Receptors, Dopamine D2 |
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| | Reverse Transcriptase Polymerase Chain Reaction |
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| | Young Adult |
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| K10plus-PPN: | 1871510139 |
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| Verknüpfungen: | → Zeitschrift |
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Frontostriatal involvement in task switching depends on genetic differences in d2 receptor density / Stelzel, Christine [VerfasserIn]; Aug. 24, 2010 (Online-Ressource)
