Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Valeriano Nunes, Ivanéia [VerfasserIn]   i
 Andrade, Camila Mattos [VerfasserIn]   i
 Guerra, Priscila Valera [VerfasserIn]   i
 Khouri, Mariana Ivo [VerfasserIn]   i
 Galantini, Maria Poliana Leite [VerfasserIn]   i
 da Silva, Robson Amaro Augusto [VerfasserIn]   i
 Faquim-Mauro, Eliana L. [VerfasserIn]   i
 Farias, Leonardo Paiva [VerfasserIn]   i
 Rebouças, Juliana de Souza [VerfasserIn]   i
 Faria, Ana Maria Caetano [VerfasserIn]   i
 Brodskyn, Cláudia Ida [VerfasserIn]   i
Titel:A new experimental model to study shrimp allergy
Verf.angabe:Ivanéia Valeriano Nunes, Camila Mattos Andrade, Priscila Valera Guerra, Mariana Ivo Khouri, Maria Poliana Leite Galantini, Robson Amaro Augusto da Silva, Eliana L. Faquim-Mauro, Leonardo Paiva Farias, Juliana de Souza Rebouças, Ana Maria Caetano Faria, Cláudia Ida Brodskyn
E-Jahr:2023
Jahr:August 2023
Umfang:8 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 28.11.2023 ; Online verfügbar: 13. Juni 2023, Version des Artikels: 5. Juli 2023
Titel Quelle:Enthalten in: Immunology letters
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1979
Jahr Quelle:2023
Band/Heft Quelle:260(2023), Seite 73-80
ISSN Quelle:1879-0542
Abstract:Shrimp is among the most sensitizing food allergens and has been associated with many anaphylaxis reactions. However, there is still a shortage of studies that enable a systematic understanding of this disease and the investigation of new therapeutic approaches. This study aimed to develop a new experimental model of shrimp allergy that could enable the evaluation of new prophylactic treatments. BALB/c mice were subcutaneously sensitized with 100 μg of shrimp proteins of Litopenaeus vannamei adsorbed in 1 mg of aluminum hydroxide on day 0, and a booster (100 µg of shrimp proteins only) on day 14. The oral challenge protocol was based on the addition of 5 mg/ml of shrimp proteins to water from day 21 to day 35. Analysis of shrimp extract content detected at least 4 of the major allergens reported to L. vannamei. In response to the sensitization, allergic mice showed significantly enhanced IL-4 and IL-10 production in restimulated cervical draining lymph node cells. High detection of serum anti-shrimp IgE and IgG1 suggested the development of allergies to shrimp while Passive Cutaneous Anaphylaxis assay revealed an IgE-mediated response. Immunoblotting analysis revealed that Allergic mice developed antibodies to multiple antigens present in the shrimp extract. These observations were supported by the detection of anti-shrimp IgA production in intestinal lavage samples and morphometric intestinal mucosal changes. Therefore, this experimental protocol can be a tool to evaluate prophylactic and therapeutic approaches.
DOI:doi:10.1016/j.imlet.2023.06.007
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.imlet.2023.06.007
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0165247823001098
 DOI: https://doi.org/10.1016/j.imlet.2023.06.007
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Eosinophils
 Food allergy
 IgE
 Intestinal mucosa
 Shrimp allergy
K10plus-PPN:1871510597
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69147407   QR-Code
zum Seitenanfang