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Verfasst von:Zittel, Sven [VerfasserIn]   i
 Moratin, Julius [VerfasserIn]   i
 Awounvo Awounvo, Junior Sinclair [VerfasserIn]   i
 Rückschloß, Thomas [VerfasserIn]   i
 Freier, Kolja [VerfasserIn]   i
 Ristow, Oliver [VerfasserIn]   i
 Engel, Michael [VerfasserIn]   i
 Hoffmann, Jürgen [VerfasserIn]   i
 Freudlsperger, Christian [VerfasserIn]   i
 Horn, Dominik [VerfasserIn]   i
Titel:Impact of salvage surgery on health-related quality of life in oral squamous cell carcinoma
Titelzusatz:a prospective multi-center study
Verf.angabe:Sven Zittel, Julius Moratin, Sinclair Awounvo, Thomas Rückschloß, Kolja Freier, Oliver Ristow, Michael Engel, Jürgen Hoffmann, Christian Freudlsperger and Dominik Horn
E-Jahr:2023
Jahr:18 October 2023
Umfang:12 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 29.11.2023
Titel Quelle:Enthalten in: Journal of Clinical Medicine
Ort Quelle:Basel : MDPI, 2012
Jahr Quelle:2023
Band/Heft Quelle:12(2023), 20, Artikel-ID 6602, Seite 1-12
ISSN Quelle:2077-0383
Abstract:Background: Patients with recurrent oral squamous cell carcinoma (OSCC) have limited treatment options. Salvage surgery offers potential curative therapy. The need for extensive ablative surgery together with microvascular reconstruction implies invasive and painful treatment with questionable functional outcome. To address the impact of salvage surgery on the health-related quality of life (HRQoL) of patients suffering from recurrent OSCC, a multi-center prospective analysis was initiated. Material and Methods: Patients with recurrent OSCC from 2015 to 2022 at two German cancer centers were included. Interdisciplinary tumor board decisions determined surgery as the only curative treatment modality. HRQoL, was assessed via a EORTC questionnaire (European Organization for Research and Treatment of Cancer—EORTC: QLQ-C30 and QLQ-H&N35) in dependence of the recurrent tumor stage. Patients completed the questionnaires once before surgery (baseline) and then every 3 months during follow-up or up to the end of treatment. Results: In total, 55 patients were included. The mean follow-up period was 26.7 ± 19.3 months. Global health status showed superior mean scores after 12 months (60.83 ± 22.58) compared to baseline (53.33 ± 26.41) in stage 1 and 2 recurrent tumors. In advanced recurrent tumors’ mean scores for global health showed only minor positive differences after 12 months (55.13 ± 22.7) compared to baseline (53.2 ± 25.58). In terms of the mouth pain, mean scores were lower after salvage surgery in small recurrent tumors after 12 months (20.37 ± 17.73) compared to baseline (41.67 ± 33.07; Wilcoxon two-sample signed-rank test p = 0.028). In advanced recurrent tumors, a significant reduction in mean scores was detected 3 months after salvage surgery (29.7 ± 22.94) compared to baseline (47.76 ± 25.77; Wilcoxon two-sample signed-rank test p = 0.003). Up to 12 months, swallowing function was evaluated inferior compared to baseline independent of tumor stage (Mean score recurrent stage I/II: 12-months 48.15 ± 27.57, baseline 28.7 ± 22.87; stage III/IV: 12-months 49.36.42 ± 27.53; baseline 30.13 ± 26.25). Conclusion: Improved HRQoL could be obtained in advanced recurrent OSCC after salvage surgery despite reduced swallowing function. In small recurrent tumors, overall, HRQoL was superior to baseline. Salvage surgery positively affected pain burden. For advanced recurrent tumors, important pain relieve could be observed as soon as 3 months after surgery.
DOI:doi:10.3390/jcm12206602
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/jcm12206602
 kostenfrei: Volltext: https://www.mdpi.com/2077-0383/12/20/6602
 DOI: https://doi.org/10.3390/jcm12206602
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:EORTC
 oral squamous cell carcinoma
 quality of life
 recurrent oral squamous cell carcinoma
 salvage surgery
K10plus-PPN:1871573947
Verknüpfungen:→ Zeitschrift

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