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| Verfasst von: | Tsitlakidis, Stefanos [VerfasserIn]  |
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| | Hohenbild, Frederike [VerfasserIn] |
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| | Saur, Merve [VerfasserIn] |
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| | Moghaddam-Alvandi, Arash [VerfasserIn] |
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| | Kunisch, Elke [VerfasserIn] |
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| | Renkawitz, Tobias [VerfasserIn] |
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| | Gonzalo-Juan, Isabel [VerfasserIn] |
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| | Westhauser, Fabian [VerfasserIn] |
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| Titel: | Reduced sodium portions favor osteogenic properties and cytocompatibility of 45S5-based bioactive glass particles |
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| Verf.angabe: | Stefanos Tsitlakidis, Frederike Hohenbild, Merve Saur, Arash Moghaddam, Elke Kunisch, Tobias Renkawitz, Isabel Gonzalo de Juan and Fabian Westhauser |
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| E-Jahr: | 2023 |
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| Jahr: | 2 October 2023 |
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| Umfang: | 17 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 01.12.2023 |
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| Titel Quelle: | Enthalten in: Biomimetics |
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| Ort Quelle: | Basel : MDPI, 2016 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 8(2023), 6, Artikel-ID 472, Seite 1-17 |
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| ISSN Quelle: | 2313-7673 |
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| Abstract: | Besides its favorable biological properties, the release of sodium (Na) from the well-known 45S5-bioactive glass (BG) composition (in mol%: 46.1, SiO2, 24.5 CaO, 24.5 Na2O, 6.0 P2O5) can hamper its cytocompatibility. In this study, particles of Na-reduced variants of 45S5-BG were produced in exchange for CaO and P2O5 via the sol-gel-route resulting in Na contents of 75%, 50%, 25% or 0% of the original composition. The release of ions from the BGs as well as their impact on the cell environment (pH values), viability and osteogenic differentiation (activity of alkaline phosphatase (ALP)), the expression of osteopontin and osteocalcin in human bone-marrow-derived mesenchymal stromal cells in correlation to the Na-content and ion release of the BGs was assessed. The release of Na-ions increased with increasing Na-content in the BGs. With decreasing Na content, the viability of cells incubated with the BGs increased. The Na-reduced BGs showed elevated ALP activity and a pro-osteogenic stimulation with accelerated osteopontin induction and a pronounced upregulation of osteocalcin. In conclusion, the reduction in Na-content enhances the cytocompatibility and improves the osteogenic properties of 45S5-BG, making the Na-reduced variants of 45S5-BG promising candidates for further experimental consideration. |
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| DOI: | doi:10.3390/biomimetics8060472 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/biomimetics8060472 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2313-7673/8/6/472 |
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| | DOI: https://doi.org/10.3390/biomimetics8060472 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | 45S5 bioactive glass |
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| | bone tissue engineering |
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| | cell viability |
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| | human mesenchymal stromal cells |
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| | osteogenic differentiation |
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| | sodium-reduced bioactive glass |
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| | sol gel |
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| K10plus-PPN: | 187176260X |
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| Verknüpfungen: | → Zeitschrift |
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Reduced sodium portions favor osteogenic properties and cytocompatibility of 45S5-based bioactive glass particles / Tsitlakidis, Stefanos [VerfasserIn]; 2 October 2023 (Online-Ressource)
