Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Figl, Adina [VerfasserIn]   i
 Scherer, Dominique [VerfasserIn]   i
 Nagore, Eduardo [VerfasserIn]   i
 Lorenzo Bermejo, Justo [VerfasserIn]   i
 Botella-Estrada, Rafael [VerfasserIn]   i
 Gast, Andreas [VerfasserIn]   i
 Thirumaran, Ranjit Kumar [VerfasserIn]   i
 Planelles, Dolores [VerfasserIn]   i
 Hemminki, Kari [VerfasserIn]   i
 Schadendorf, Dirk [VerfasserIn]   i
 Kumar, Rajiv [VerfasserIn]   i
Titel:Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma
Verf.angabe:Adina Figl, Dominique Scherer, Eduardo Nagore, Justo Lorenzo Bermejo, Rafael Botella-Estrada, Andreas Gast, Ranjit K. Thirumaran, Dolores Planelles, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar
E-Jahr:2010
Jahr:26 June 2010
Umfang:9 S.
Fussnoten:Gesehen am 04.12.2023
Titel Quelle:Enthalten in: Mutation research. Genetic toxicology and environmental mutagenesis
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1997
Jahr Quelle:2010
Band/Heft Quelle:702(2010), 1 vom: Sept., Seite 8-16
ISSN Quelle:1388-2120
Abstract:Single-nucleotide polymorphisms in different DNA-repair genes are reported to modulate risk of various cancers including melanoma. We genotyped DNA from 1186 melanoma patients and 1280 healthy controls for 13 different polymorphisms in eight DNA-repair genes. Data analyses showed that none of the polymorphisms except T241M XRCC3 was associated with an increased risk for cutaneous melanoma. Carriers of the variant alleles were associated with a decreased risk (OR 0.83; 95% CI, 0.79-0.98). Three additional polymorphisms together with T241M XRCC3 that tagged the entire gene region and the neighbouring genes KLC1, ZFYVE21 and PPP1R13B were not associated with the disease risk; neither were the inferred haplotypes. Imputation showed association of comparable magnitude with 11 non-genotyped neighbouring polymorphisms. Finally, the combination of results for all polymorphisms genotyped in the present study with published data suggests that none of the investigated polymorphisms was associated with melanoma susceptibility. We conclude that 13 non-synonymous polymorphisms in eight DNA-repair genes that are frequently investigated with respect to modulation of cancer risk in populations are not associated with susceptibility to cutaneous melanoma.
DOI:doi:10.1016/j.mrgentox.2010.06.011
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.mrgentox.2010.06.011
 Volltext: https://www.sciencedirect.com/science/article/pii/S1383571810002226?via%3Dihub
 DOI: https://doi.org/10.1016/j.mrgentox.2010.06.011
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:DNA Repair
 DNA-Binding Proteins
 Female
 Humans
 Kinesins
 Male
 Melanoma
 Polymorphism, Single Nucleotide
 Skin Neoplasms
K10plus-PPN:1871820847
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69148773   QR-Code
zum Seitenanfang