| Online-Ressource |
Verfasst von: | Herrmann, Markus [VerfasserIn]  |
| Zelzer, Sieglinde [VerfasserIn]  |
| Cavalier, Etienne [VerfasserIn]  |
| Kleber, Marcus E. [VerfasserIn]  |
| Drexler-Helmberg, Camilla [VerfasserIn]  |
| Schlenke, Peter [VerfasserIn]  |
| Curcic, Pero [VerfasserIn]  |
| Keppel, Martin H [VerfasserIn]  |
| Enko, Dietmar [VerfasserIn]  |
| Scharnagl, Hubert [VerfasserIn]  |
| Pilz, Stefan [VerfasserIn]  |
| März, Winfried [VerfasserIn]  |
Titel: | Functional assessment of vitamin D status by a novel metabolic approach |
Titelzusatz: | the low vitamin D profile concept |
Verf.angabe: | Markus Herrmann, Sieglinde Zelzer, Etienne Cavalier, Marcus Kleber, Camilla Drexler-Helmberg, Peter Schlenke, Pero Curcic, Martin H Keppel, Dietmar Enko, Hubert Scharnagl, Stefan Pilz, and Winfried März |
E-Jahr: | 2023 |
Jahr: | 05 October 2023 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 05.12.2023 |
Titel Quelle: | Enthalten in: Clinical chemistry |
Ort Quelle: | Washington, DC : American Association for Clinical Chemistry, 1955 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 69(2023), 11, Seite 1307-1316 |
ISSN Quelle: | 1530-8561 |
Abstract: | Abstract - Background - Determining serum 25-hydroxyvitamin D [25(OH)D], 24,25-dihydroxyvitamin D [24,25(OH)2D] and the vitamin D metabolite ratio (VMR) allows the identification of individuals with a low vitamin D metabolite profile. Here, we evaluated if such a functional approach provides superior diagnostic information to serum 25(OH)D alone. - Methods - 25(OH)D, 24,25(OH)2D, and the VMR were determined in participants of the DESIRE (Desirable Vitamin D Concentrations, n = 2010) and the LURIC (Ludwigshafen Risk and Cardiovascular Health, n = 2456) studies. A low vitamin D metabolite profile (vitamin D insufficiency) was defined by a 24,25(OH)2D concentration <1.2 ng/mL (<3 nmol/L) and a VMR <4%. Parathyroid hormone (PTH) and bone turnover markers were measured in both cohorts, whereas 10-year mortality data was recorded in LURIC only. - Results - The median age in DESIRE and LURIC was 43.3 and 63.8 years, respectively. Median 25(OH)D concentrations were 27.2 ng/mL (68.0 nmol/L) and 15.5 ng/mL (38.8 nmol/L), respectively. Serum 25(OH)D deficiency, defined as <20.2 ng/mL (<50 nmol/L), was present in 483 (24.0%) and 1701 (69.3%) participants of DESIRE and LURIC, respectively. In contrast, only 77 (3.8%) and 521 (21.2%) participants had a low vitamin D metabolite profile. Regardless of the serum 25(OH)D concentration, a low vitamin D metabolite profile was associated with a significantly higher PTH, accelerated bone metabolism, and higher all-cause mortality than an unremarkable vitamin D metabolite profile. - Conclusions - The personalized assessment of vitamin D status using a functional approach better identifies patients with accelerated bone metabolism and increased mortality than the use of a fixed 25(OH)D cutoff of 20 ng/mL (50 nmol/L). |
DOI: | doi:10.1093/clinchem/hvad151 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/clinchem/hvad151 |
| Volltext: https://academic.oup.com/clinchem/article/69/11/1307/7292901 |
| DOI: https://doi.org/10.1093/clinchem/hvad151 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1871920698 |
Verknüpfungen: | → Zeitschrift |
Functional assessment of vitamin D status by a novel metabolic approach / Herrmann, Markus [VerfasserIn]; 05 October 2023 (Online-Ressource)