| |  Online-Ressource |
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| Verfasst von: | Höhn, Julia [VerfasserIn]  |
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| | Krieghoff-Henning, Eva [VerfasserIn] |
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| | Wies, Christoph [VerfasserIn] |
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| | Kiehl, Lennard [VerfasserIn] |
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| | Hetz, Martin J. [VerfasserIn] |
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| | Bucher, Tabea-Clara [VerfasserIn] |
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| | Jonnagaddala, Jitendra [VerfasserIn] |
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| | Zatloukal, Kurt [VerfasserIn] |
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| | Müller, Heimo [VerfasserIn] |
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| | Plass, Markus [VerfasserIn] |
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| | Jungwirth, Emilian [VerfasserIn] |
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| | Gaiser, Timo [VerfasserIn] |
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| | Steeg, Matthias [VerfasserIn] |
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| | Holland-Letz, Tim [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| | Hoffmeister, Michael [VerfasserIn] |
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| | Brinker, Titus Josef [VerfasserIn] |
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| Titel: | Colorectal cancer risk stratification on histological slides based on survival curves predicted by deep learning |
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| Verf.angabe: | Julia Höhn, Eva Krieghoff-Henning, Christoph Wies, Lennard Kiehl, Martin J. Hetz, Tabea-Clara Bucher, Jitendra Jonnagaddala, Kurt Zatloukal, Heimo Müller, Markus Plass, Emilian Jungwirth, Timo Gaiser, Matthias Steeg, Tim Holland-Letz, Hermann Brenner, Michael Hoffmeister and Titus J. Brinker |
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| E-Jahr: | 2023 |
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| Jahr: | 26 September 2023 |
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| Umfang: | 12 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 26. September 2023 ; Gesehen am 05.12.2023 |
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| Titel Quelle: | Enthalten in: npj precision oncology |
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| Ort Quelle: | [London] : Springer Nature, 2017 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 7(2023), Artikel-ID 98, Seite 1-12 |
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| ISSN Quelle: | 2397-768X |
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| Abstract: | Studies have shown that colorectal cancer prognosis can be predicted by deep learning-based analysis of histological tissue sections of the primary tumor. So far, this has been achieved using a binary prediction. Survival curves might contain more detailed information and thus enable a more fine-grained risk prediction. Therefore, we established survival curve-based CRC survival predictors and benchmarked them against standard binary survival predictors, comparing their performance extensively on the clinical high and low risk subsets of one internal and three external cohorts. Survival curve-based risk prediction achieved a very similar risk stratification to binary risk prediction for this task. Exchanging other components of the pipeline, namely input tissue and feature extractor, had largely identical effects on model performance independently of the type of risk prediction. An ensemble of all survival curve-based models exhibited a more robust performance, as did a similar ensemble based on binary risk prediction. Patients could be further stratified within clinical risk groups. However, performance still varied across cohorts, indicating limited generalization of all investigated image analysis pipelines, whereas models using clinical data performed robustly on all cohorts. |
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| DOI: | doi:10.1038/s41698-023-00451-3 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41698-023-00451-3 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41698-023-00451-3 |
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| | DOI: https://doi.org/10.1038/s41698-023-00451-3 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Colorectal cancer |
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| | Mathematics and computing |
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| | Prognostic markers |
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| K10plus-PPN: | 1871925398 |
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| Verknüpfungen: | → Zeitschrift |
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Colorectal cancer risk stratification on histological slides based on survival curves predicted by deep learning / Höhn, Julia [VerfasserIn]; 26 September 2023 (Online-Ressource)
