Bispidine chelators for radiopharmaceutical applications with lanthanide, actinide, and main group metal ions

• Verfasst von: Kopp, Ina [VerfasserIn]
• Verfasst von: Cieslik, Patrick [VerfasserIn]
• Verfasst von: Anger, Karl [VerfasserIn]
• Verfasst von: Josephy, Thomas [VerfasserIn]
• Verfasst von: Neupert, Lucca [VerfasserIn]
• Verfasst von: Velmurugan, Gunasekaran [VerfasserIn]
• Verfasst von: Gast, Michael [VerfasserIn]
• Verfasst von: Wadepohl, Hubert [VerfasserIn]
• Verfasst von: Brühlmann, Santiago Andrés [VerfasserIn]
• Verfasst von: Walther, Martin [VerfasserIn]
• Verfasst von: Kopka, Klaus [VerfasserIn]
• Verfasst von: Bachmann, Michael [VerfasserIn]
• Verfasst von: Stephan, Holger [VerfasserIn]
• Verfasst von: Kubeil, Manja [VerfasserIn]
• Verfasst von: Comba, Peter [VerfasserIn]
• Titel: Bispidine chelators for radiopharmaceutical applications with lanthanide, actinide, and main group metal ions
• Verf.angabe: Ina Kopp, Patrick Cieslik, Karl Anger, Thomas Josephy, Lucca Neupert, Gunasekaran Velmurugan, Michael Gast, Hubert Wadepohl, Santiago Andrés Brühlmann, Martin Walther, Klaus Kopka, Michael Bachmann, Holger Stephan, Manja Kubeil, and Peter Comba
• E-Jahr: 2023
• Jahr: 14 September 2023
• Umfang: 15 S.
• Fussnoten: Online veröffentlicht: 14. September 2023 ; Gesehen am 05.12.2023
• Titel Quelle: Enthalten in: Inorganic chemistry
• Ort Quelle: Washington, DC : American Chemical Society, 1962
• Jahr Quelle: 2023
• Band/Heft Quelle: (2023), online ahead of print
• ISSN Quelle: 1520-510X
• DOI: doi:10.1021/acs.inorgchem.3c02340
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1871926645

Abstract

Octadentate and specifically nonadentate ligands with a bispidine scaffold (3,7-diazabicyclo[3.3.1]nonane) are known to be efficiently coordinated to a range of metal ions of interest in radiopharmaceutical chemistry and lead to exceedingly stable and inert complexes. Nonadentate bispidine L2 (with a tridentate bipyridine acetate appended to N3 and a picolinate at N7) has been shown before to be an ideal chelator for 111In3+, 177Lu3+, and 225Ac3+, nuclides of interest for diagnosis and therapy, and a proof-of-principle study with an SSTR2-specific octreotate has shown potential for theranostic applications. We now have extended these studies in two directions. First, we present ligand derivative L3, in which the bipyridine acetate is substituted with terpyridine, a softer donor for metal ions with a preference for more covalency. L3 did not fulfill the hopes because complexation is much less efficient. While for Bi3+ and Pb2+ the ligand is an excellent chelator with properties similar to those of L2, Lu3+ and La3+ show very slow and inefficient complexation with L3 in contrast to L2, and 225Ac3+ is not fully coordinated, even at an increased temperature (92% radiochemical yield at 80 °C, 60 min, [L3] = 10-4 M). These observations have led to a hypothesis for the complexation pathway that is in line with all of the experimental data and supported by a preliminary density functional theory analysis, which is important for the design of further optimized bispidine chelators. Second, the coordination chemistry of L2 has been extended to Bi3+, La3+, and Pb2+, including solid state and solution structural work, complex stabilities, radiolabeling, and radiostability studies. All complexes of this ligand (La3+, Ac3+, Lu3+, Bi3+, In3+, and Pb2+), including nuclides for targeted α therapy (TAT), single-photon emission computed tomography, and positron emission tomography, are formed efficiently under physiological conditions, i.e., suitable for the labeling of delicate biological vectors such as antibodies, and the complexes are very stable and inert. Importantly, for TAT with 225Ac, the daughter nuclides 213Bi and 209Pb also form stable complexes, and this is important for reducing damage to healthy tissue.