| |  Online-Ressource |
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| Verfasst von: | Bódis, Kálmán Benedikt [VerfasserIn]  |
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| | Bombrich, Maria [VerfasserIn] |
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| | Schön, Martin [VerfasserIn] |
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| | Knebel, Birgit [VerfasserIn] |
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| | Zaharia, Oana-Patricia [VerfasserIn] |
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| | Bönhof, Gidon [VerfasserIn] |
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| | Karusheva, Yanislava [VerfasserIn] |
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| | Strassburger, Klaus [VerfasserIn] |
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| | Kupriyanova, Yuliya [VerfasserIn] |
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| | Kotzka, Jörg [VerfasserIn] |
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| | Guthoff, Rainer [VerfasserIn] |
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| | Schrauwen-Hinderling, Vera [VerfasserIn] |
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| | Al-Hasani, Hadi [VerfasserIn] |
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| | Burkart, Volker [VerfasserIn] |
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| | Szendrödi, Julia [VerfasserIn] |
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| | Wagner, Robert [VerfasserIn] |
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| | Markgraf, Daniel F. [VerfasserIn] |
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| | Roden, Michael [VerfasserIn] |
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| Titel: | Effects of TM6SF2 rs58542926 polymorphism on hepatocellular lipids and insulin resistance in early type 2 diabetes |
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| Verf.angabe: | Kálmán Bódis, Maria Bombrich, Martin Schön, Birgit Knebel, Oana-Patricia Zaharia, Gidon Bönhof, Yanislava Karusheva, Klaus Strassburger, Yuliya Kupriyanova, Jörg Kotzka, Rainer Guthoff, Vera Schrauwen-Hinderling, Hadi Al-Hasani, Volker Burkart, Julia Szendroedi, Robert Wagner, Daniel F. Markgraf, Michael Roden, for the GDS study group |
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| E-Jahr: | 2023 |
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| Jahr: | September 2023 |
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| Umfang: | 12 S. |
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| Fussnoten: | Online verfügbar 9 June 2023, Version des Artikels 11 August 2023 ; Gesehen am 06.12.2023 |
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| Titel Quelle: | Enthalten in: Nutrition, metabolism and cardiovascular diseases |
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| Ort Quelle: | New York, NY [u.a.] : Elsevier, 2001 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 33(2023), 9 vom: Sept., Seite 1785-1796 |
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| ISSN Quelle: | 1590-3729 |
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| Abstract: | Background and aims - Increased hepatocellular lipid content (HCL) is linked to insulin resistance, risk of type 2 diabetes and related complications. Conversely, a single-nucleotide polymorphism (TM6SF2EK; rs58542926) in the transmembrane 6 superfamily member 2-gene has been associated with nonalcoholic fatty liver disease (NAFLD), but lower cardiovascular risk. This case-control study tested the role of this polymorphism for tissue-specific insulin sensitivity during early course of diabetes. - Methods and results - Males with recent-onset type 2 diabetes with (TM6SF2EK: n = 16) or without (TM6SF2EE: n = 16) the heterozygous TM6SF2-polymorphism of similar age and body mass index, underwent Botnia-clamps with [6,6-2H2]glucose to measure whole-body-, hepatic- and adipose tissue-insulin sensitivity. HCL was assessed with 1H-magnetic-resonance-spectroscopy. A subset of both groups (n = 24) was re-evaluated after 5 years. Despite doubled HCL, TM6SF2EK had similar hepatic- and adipose tissue-insulin sensitivity and 27% higher whole-body-insulin sensitivity than TM6SF2EE. After 5 years, whole-body-insulin sensitivity, HCL were similar between groups, while adipose tissue-insulin sensitivity decreased by 87% and 55% within both groups and circulating triacylglycerol increased in TM6SF2EE only. - Conclusions - The TM6SF2-polymorphism rs58542926 dissociates HCL from insulin resistance in recent-onset type 2 diabetes, which is attenuated by disease duration. This suggests that diabetes-related metabolic alterations dominate over effects of the TM6SF2-polymorphism during early course of diabetes and NAFLD. |
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| DOI: | doi:10.1016/j.numecd.2023.06.004 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.numecd.2023.06.004 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0939475323002375 |
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| | DOI: https://doi.org/10.1016/j.numecd.2023.06.004 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Hepatocellular lipid content |
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| | Insulin sensitivity |
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| | Nonalcoholic fatty liver disease |
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| | Transmembrane 6 superfamily member 2 |
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| | Type 2 diabetes |
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| K10plus-PPN: | 1872121004 |
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| Verknüpfungen: | → Zeitschrift |
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Effects of TM6SF2 rs58542926 polymorphism on hepatocellular lipids and insulin resistance in early type 2 diabetes / Bódis, Kálmán Benedikt [VerfasserIn]; September 2023 (Online-Ressource)
