| |  Online-Ressource |
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| Verfasst von: | Stocker, Hannah [VerfasserIn]  |
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| | Trares, Kira [VerfasserIn] |
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| | Beyer, Léon [VerfasserIn] |
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| | Perna, Laura [VerfasserIn] |
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| | Rujescu, Dan [VerfasserIn] |
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| | Holleczek, Bernd [VerfasserIn] |
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| | Beyreuther, Konrad [VerfasserIn] |
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| | Gerwert, Klaus [VerfasserIn] |
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| | Schöttker, Ben [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| Titel: | Alzheimer’s polygenic risk scores, APOE, Alzheimer’s disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years |
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| Verf.angabe: | Hannah Stocker, Kira Trares, Léon Beyer, Laura Perna, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Klaus Gerwert, Ben Schöttker and Hermann Brenner |
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| E-Jahr: | 2023 |
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| Jahr: | 29 July 2023 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 07.12.2023 |
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| Titel Quelle: | Enthalten in: Alzheimer's research & therapy |
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| Ort Quelle: | London : BioMed Central, 2009 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 15(2023), Artikel-ID 129, Seite 1-9 |
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| ISSN Quelle: | 1758-9193 |
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| Abstract: | In order to utilize polygenic risk scores (PRSs) for Alzheimer’s disease (AD) in a meaningful way, influential factors (i.e. training set) and prediction across groups such as APOE e4 (APOE4) genotype as well as associations to dementia-related biomarkers should be explored. Therefore, we examined the association of APOE4 and various PRSs, based on training sets that utilized differing AD definitions, with incident AD and all-cause dementia (ACD) within 17 years, and with levels of phosphorylated tau181 (P-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) in blood. Secondarily, effect modification by APOE4 status and sex was examined. |
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| DOI: | doi:10.1186/s13195-023-01277-8 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1186/s13195-023-01277-8 |
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| | kostenfrei: Volltext: https://alzres.biomedcentral.com/articles/10.1186/s13195-023-01277-8 |
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| | DOI: https://doi.org/10.1186/s13195-023-01277-8 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Alzheimer’s disease |
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| | Blood-biomarkers |
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| | Polygenic risk scores |
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| K10plus-PPN: | 1872237827 |
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| Verknüpfungen: | → Zeitschrift |
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Alzheimer’s polygenic risk scores, APOE, Alzheimer’s disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years / Stocker, Hannah [VerfasserIn]; 29 July 2023 (Online-Ressource)
