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| Verfasst von: | Hamidi, Fardin [VerfasserIn]  |
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| | Anwari, Elaaha [VerfasserIn] |
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| | Spaulding, Christian [VerfasserIn] |
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| | Hauw-Berlemont, Caroline [VerfasserIn] |
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| | Vilfaillot, Aurélie [VerfasserIn] |
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| | Viana-Tejedor, Ana [VerfasserIn] |
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| | Kern, Karl B. [VerfasserIn] |
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| | Hsu, Chiu-Hsieh [VerfasserIn] |
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| | Bergmark, Brian A. [VerfasserIn] |
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| | Qamar, Arman [VerfasserIn] |
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| | Bhatt, Deepak L. [VerfasserIn] |
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| | Furtado, Remo H. M. [VerfasserIn] |
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| | Myhre, Peder L. [VerfasserIn] |
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| | Hengstenberg, Christian [VerfasserIn] |
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| | Lang, Irene M. [VerfasserIn] |
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| | Frey, Norbert [VerfasserIn] |
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| | Freund, Anne [VerfasserIn] |
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| | Desch, Steffen [VerfasserIn] |
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| | Thiele, Holger [VerfasserIn] |
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| | Preusch, Michael [VerfasserIn] |
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| | Zelniker, Thomas [VerfasserIn] |
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| Titel: | Early versus delayed coronary angiography in patients with out-of-hospital cardiac arrest and no ST-segment elevation |
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| Titelzusatz: | a systematic review and meta-analysis of randomized controlled trials |
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| Verf.angabe: | Fardin Hamidi, Elaaha Anwari, Christian Spaulding, Caroline Hauw-Berlemont, Aurélie Vilfaillot, Ana Viana-Tejedor, Karl B. Kern, Chiu-Hsieh Hsu, Brian A. Bergmark, Arman Qamar, Deepak L. Bhatt, Remo H.M. Furtado, Peder L. Myhre, Christian Hengstenberg, Irene M. Lang, Norbert Frey, Anne Freund, Steffen Desch, Holger Thiele, Michael R. Preusch, Thomas A. Zelniker |
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| E-Jahr: | 2023 |
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| Jahr: | 27 July 2023 |
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| Umfang: | 9 S. |
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| Fussnoten: | Online veröffentlicht: 27. Juli 2023 ; Gesehen am 08.12.2023 |
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| Titel Quelle: | Enthalten in: Clinical research in cardiology |
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| Ort Quelle: | Berlin : Springer, 2006 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 113(2023), 4, Seite 561-569 |
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| ISSN Quelle: | 1861-0692 |
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| Abstract: | Background: Recent randomized controlled trials did not show benefit of early/immediate coronary angiography (CAG) over a delayed/selective strategy in patients with out-of-hospital cardiac arrest (OHCA) and no ST-segment elevation. However, whether selected subgroups, specifically those with a high pretest probability of coronary artery disease may benefit from early CAG remains unclear. Methods: We included all randomized controlled trials that compared a strategy of early/immediate versus delayed/selective CAG in OHCA patients and no ST elevation and had a follow-up of at least 30 days. The primary outcome of interest was all-cause death. Odds ratios (OR) were calculated and pooled across trials. Interaction testing was used to assess for heterogeneity of treatment effects. Results: In total, 1512 patients (67 years, 26% female, 23% prior myocardial infarction) were included from 5 randomized controlled trials. Early/immediate versus delayed/selective CAG was not associated with a statistically significant difference in odds of death (OR 1.12, 95%-CI 0.91–1.38), with similar findings for the composite outcome of all-cause death or neurological deficit (OR 1.10, 95%-CI 0.89–1.36). There was no effect modification for death by age, presence of a shockable initial cardiac rhythm, history of coronary artery disease, presence of an ischemic event as the presumed cause of arrest, or time to return of spontaneous circulation (all P-interaction > 0.10). However, early/immediate CAG tended to be associated with higher odds of death in women (OR 1.52, 95%-CI 1.00–2.31, P = 0.050) than in men (OR 1.04, 95%-CI 0.82–1.33, P = 0.74; P-interaction 0.097). Conclusion: In OHCA patients without ST-segment elevation, a strategy of early/immediate versus delayed/selective CAG did not reduce all-cause mortality across major subgroups. However, women tended to have higher odds of death with early CAG. |
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| DOI: | doi:10.1007/s00392-023-02264-7 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1007/s00392-023-02264-7 |
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| | DOI: https://doi.org/10.1007/s00392-023-02264-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Coronary angiography |
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| | Critical care medicine |
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| | Out-of-hospital cardiac arrest |
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| | Percutaneous coronary intervention |
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| K10plus-PPN: | 1872977588 |
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| Verknüpfungen: | → Zeitschrift |
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Early versus delayed coronary angiography in patients with out-of-hospital cardiac arrest and no ST-segment elevation / Hamidi, Fardin [VerfasserIn]; 27 July 2023 (Online-Ressource)
