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| Verfasst von: | Pertz, Milena [VerfasserIn]  |
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| | Schlömer, Sabine [VerfasserIn] |
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| | Seidel, Clemens [VerfasserIn] |
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| | Hentschel, Bettina [VerfasserIn] |
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| | Löffler, Markus [VerfasserIn] |
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| | Schackert, Gabriele [VerfasserIn] |
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| | Krex, Dietmar [VerfasserIn] |
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| | Juratli, Tareq [VerfasserIn] |
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| | Tonn, Joerg Christian [VerfasserIn] |
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| | Schnell, Oliver [VerfasserIn] |
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| | Vatter, Hartmut [VerfasserIn] |
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| | Simon, Matthias [VerfasserIn] |
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| | Westphal, Manfred [VerfasserIn] |
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| | Martens, Tobias [VerfasserIn] |
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| | Sabel, Michael [VerfasserIn] |
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| | Bendszus, Martin [VerfasserIn] |
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| | Dörner, Nils [VerfasserIn] |
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| | Wick, Antje [VerfasserIn] |
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| | Fliessbach, Klaus [VerfasserIn] |
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| | Hoppe, Christian [VerfasserIn] |
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| | Klingner, Marcel [VerfasserIn] |
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| | Felsberg, Jörg [VerfasserIn] |
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| | Reifenberger, Guido [VerfasserIn] |
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| | Gramatzki, Dorothee [VerfasserIn] |
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| | Weller, Michael [VerfasserIn] |
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| | Schlegel, Uwe [VerfasserIn] |
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| Titel: | Long-term neurocognitive function and quality of life after multimodal therapy in adult glioma patients |
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| Titelzusatz: | a prospective long-term follow-up |
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| Verf.angabe: | Milena Pertz, Sabine Schlömer, Clemens Seidel, Bettina Hentschel, Markus Löffler, Gabriele Schackert, Dietmar Krex, Tareq Juratli, Joerg Christian Tonn, Oliver Schnell, Hartmut Vatter, Matthias Simon, Manfred Westphal, Tobias Martens, Michael Sabel, Martin Bendszus, Nils Dörner, Antje Wick, Klaus Fliessbach, Christian Hoppe, Marcel Klingner, Jörg Felsberg, Guido Reifenberger, Dorothee Gramatzki, Michael Weller, Uwe Schlegel, for the German Glioma Network |
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| E-Jahr: | 2023 |
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| Jahr: | 30 August 2023 |
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| Umfang: | 14 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 30. August 2023 ; Gesehen am 08.12.2023 |
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| Titel Quelle: | Enthalten in: Journal of neuro-oncology |
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| Ort Quelle: | Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 164(2023), 2, Seite 353-366 |
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| ISSN Quelle: | 1573-7373 |
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| Abstract: | Purpose: Multimodal therapies have significantly improved prognosis in glioma. However, in particular radiotherapy may induce long-term neurotoxicity compromising patients’ neurocognition and quality of life. The present prospective multicenter study aimed to evaluate associations of multimodal treatment with neurocognition with a particular focus on hippocampal irradiation. Methods: Seventy-one glioma patients (WHO grade 1–4) were serially evaluated with neurocognitive testing and quality of life questionnaires. Prior to (baseline) and following further treatment (median 7.1 years [range 4.6–11.0] after baseline) a standardized computerized neurocognitive test battery (NeuroCog FX) was applied to gauge psychomotor speed and inhibition, verbal short-term memory, working memory, verbal and non-verbal memory as well as verbal fluency. Mean ipsilateral hippocampal radiation dose was determined in a subgroup of 27 patients who received radiotherapy according to radiotherapy plans to evaluate its association with neurocognition. Results: Between baseline and follow-up mean performance in none of the cognitive domains significantly declined in any treatment modality (radiotherapy, chemotherapy, combined radio-chemotherapy, watchful-waiting), except for selective attention in patients receiving chemotherapy alone. Apart from one subtest (inhibition), mean ipsilateral hippocampal radiation dose > 50 Gy (Dmean) as compared to < 10 Gy showed no associations with long-term cognitive functioning. However, patients with Dmean < 10 Gy showed stable or improved performance in all cognitive domains, while patients with > 50 Gy numerically deteriorated in 4/8 domains. Conclusions: Multimodal glioma therapy seems to affect neurocognition less than generally assumed. Even patients with unilateral hippocampal irradiation with > 50 Gy showed no profound cognitive decline in this series. |
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| DOI: | doi:10.1007/s11060-023-04419-y |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1007/s11060-023-04419-y |
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| | DOI: https://doi.org/10.1007/s11060-023-04419-y |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Glioma |
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| | Multimodal tumor-directed treatment |
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| | Neurocognition |
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| | Quality of life |
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| | Radiotherapy |
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| K10plus-PPN: | 1872981135 |
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| Verknüpfungen: | → Zeitschrift |
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Long-term neurocognitive function and quality of life after multimodal therapy in adult glioma patients / Pertz, Milena [VerfasserIn]; 30 August 2023 (Online-Ressource)
