Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Lavallée, Philippa [VerfasserIn]   i
 Charles, Hugo [VerfasserIn]   i
 Albers, Gregory W. [VerfasserIn]   i
 Caplan, Louis R. [VerfasserIn]   i
 Donnan, Geoffrey A. [VerfasserIn]   i
 Ferro, José M. [VerfasserIn]   i
 Hennerici, Michael G. [VerfasserIn]   i
 Labreuche, Julien [VerfasserIn]   i
 Molina, Carlos [VerfasserIn]   i
 Rothwell, Peter M. [VerfasserIn]   i
 Steg, Philippe Gabriel [VerfasserIn]   i
 Touboul, Pierre-Jean [VerfasserIn]   i
 Uchiyama, Shinichiro [VerfasserIn]   i
 Vicaut, Éric [VerfasserIn]   i
 Wong, Lawrence K. S. [VerfasserIn]   i
 Amarenco, Pierre [VerfasserIn]   i
Titel:Underlying causes of TIA and minor ischemic stroke and risk of major vascular events
Verf.angabe:Philippa C. Lavallée, MD, Hugo Charles, BST, Gregory W. Albers, MD, Louis R. Caplan, MD, Geoffrey A. Donnan, MD, José M. Ferro, MD, Michael G. Hennerici, MD, Julien Labreuche, BST, Carlos Molina, MD, Peter M. Rothwell, MD, Philippe Gabriel Steg, MD, Pierre-Jean Touboul, MD, Shinichiro Uchiyama, MD, Éric Vicaut, MD, Lawrence K. S.Wong, MD, Pierre Amarenco, MD, for the TIAregistry.org Investigators
E-Jahr:2023
Jahr:October 2, 2023
Umfang:10 S.
Illustrationen:Illustrationen
Fussnoten:Online veröffentlicht: 2. Oktober 2023 ; Gesehen am 11.12.2023
Titel Quelle:Enthalten in: JAMA neurology
Ort Quelle:Chicago, Ill. : American Medical Association, 2013
Jahr Quelle:2023
Band/Heft Quelle:80(2023), 11, Seite 1199-1208
ISSN Quelle:2168-6157
Abstract:The coexistence of underlying causes in patients with transient ischemic attack (TIA) or minor ischemic stroke as well as their associated 5-year risks are not well known.To apply the ASCOD (atherosclerosis, small vessel disease, cardiac pathology, other cause, or dissection) grading system to assess coexistence of underlying causes of TIA and minor ischemic stroke and the 5-year risk for major vascular events.This international registry cohort (TIAregistry.org) study enrolled 4789 patients from June 1, 2009, to December 31, 2011, with 1- to 5-year follow-up at 61 sites in 21 countries. Eligible patients had a TIA or minor stroke (with modified Rankin Scale score of 0 or 1) within the last 7 days. Among these, 3847 patients completed the 5-year follow-up by December 31, 2016. Data were analyzed from October 1, 2022, to June 15, 2023.Five-year follow-up.Estimated 5-year risk of the composite outcome of stroke, acute coronary syndrome, or cardiovascular death.A total of 3847 patients (mean [SD] age, 66.4 [13.2] years; 2295 men [59.7%]) in 42 sites were enrolled and participated in the 5-year follow-up cohort (median percentage of 5-year follow-up per center was 92.3% [IQR, 83.4%-97.8%]). In 998 patients with probable or possible causal atherosclerotic disease, 489 (49.0%) had some form of small vessel disease (SVD), including 110 (11.0%) in whom a lacunar stroke was also probably or possibly causal, and 504 (50.5%) had no SVD; 275 (27.6%) had some cardiac findings, including 225 (22.6%) in whom cardiac pathology was also probably or possibly causal, and 702 (70.3%) had no cardiac findings. Compared with patients with none of the 5 ASCOD categories of disease (n = 484), the 5-year rate of major vascular events was almost 5 times higher (hazard ratio [HR], 4.86 [95% CI, 3.07-7.72]; P < .001) in patients with causal atherosclerosis, 2.5 times higher (HR, 2.57 [95% CI, 1.58-4.20]; P < .001) in patients with causal lacunar stroke or lacunar syndrome, and 4 times higher (HR, 4.01 [95% CI, 2.50-6.44]; P < .001) in patients with causal cardiac pathology.The findings of this cohort study suggest that in patients with TIA and minor ischemic stroke, the coexistence of atherosclerosis, SVD, cardiac pathology, dissection, or other causes is substantial, and the 5-year risk of a major vascular event varies considerably across the 5 categories of underlying diseases. These findings further suggest the need for secondary prevention strategies based on pathophysiology rather than a one-size-fits-all approach.
DOI:doi:10.1001/jamaneurol.2023.3344
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1001/jamaneurol.2023.3344
 DOI: https://doi.org/10.1001/jamaneurol.2023.3344
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1873025602
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69151405   QR-Code
zum Seitenanfang