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| Verfasst von: | Okonechnikov, Konstantin [VerfasserIn]  |
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| | Camgöz, Aylin [VerfasserIn] |
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| | Chapman, Owen [VerfasserIn] |
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| | Wani, Sameena [VerfasserIn] |
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| | Park, Donglim Esther [VerfasserIn] |
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| | Hübner, Jens-Martin [VerfasserIn] |
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| | Chakraborty, Abhijit [VerfasserIn] |
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| | Pagadala, Meghana [VerfasserIn] |
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| | Bump, Rosalind [VerfasserIn] |
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| | Chandran, Sahaana [VerfasserIn] |
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| | Kraft, Katerina [VerfasserIn] |
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| | Acuna-Hidalgo, Rocio [VerfasserIn] |
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| | Reid, Derek [VerfasserIn] |
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| | Sikkink, Kristin [VerfasserIn] |
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| | Mauermann, Monika [VerfasserIn] |
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| | Juarez, Edwin F. [VerfasserIn] |
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| | Jenseit, Anne [VerfasserIn] |
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| | Robinson, James T. [VerfasserIn] |
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| | Pajtler, Kristian Wilfried [VerfasserIn] |
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| | Milde, Till [VerfasserIn] |
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| | Jäger, Natalie [VerfasserIn] |
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| | Fiesel, Petra [VerfasserIn] |
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| | Morgan, Ling [VerfasserIn] |
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| | Sridhar, Sunita [VerfasserIn] |
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| | Coufal, Nicole G. [VerfasserIn] |
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| | Levy, Michael [VerfasserIn] |
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| | Malicki, Denise [VerfasserIn] |
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| | Hobbs, Charlotte [VerfasserIn] |
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| | Kingsmore, Stephen [VerfasserIn] |
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| | Nahas, Shareef [VerfasserIn] |
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| | Snuderl, Matija [VerfasserIn] |
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| | Crawford, John [VerfasserIn] |
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| | Wechsler-Reya, Robert J. [VerfasserIn] |
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| | Davidson, Tom Belle [VerfasserIn] |
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| | Cotter, Jennifer [VerfasserIn] |
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| | Michaiel, George [VerfasserIn] |
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| | Fleischhack, Gudrun [VerfasserIn] |
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| | Mundlos, Stefan [VerfasserIn] |
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| | Schmitt, Anthony [VerfasserIn] |
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| | Carter, Hannah [VerfasserIn] |
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| | Michealraj, Kulandaimanuvel Antony [VerfasserIn] |
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| | Kumar, Sachin A. [VerfasserIn] |
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| | Taylor, Michael D. [VerfasserIn] |
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| | Rich, Jeremy [VerfasserIn] |
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| | Buchholz, Frank [VerfasserIn] |
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| | Mesirov, Jill P. [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Ay, Ferhat [VerfasserIn] |
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| | Dixon, Jesse R. [VerfasserIn] |
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| | Kool, Marcel [VerfasserIn] |
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| | Chavez, Lukas [VerfasserIn] |
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| Titel: | 3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma |
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| Verf.angabe: | Konstantin Okonechnikov, Aylin Camgöz, Owen Chapman, Sameena Wani, Donglim Esther Park, Jens-Martin Hübner, Abhijit Chakraborty, Meghana Pagadala, Rosalind Bump, Sahaana Chandran, Katerina Kraft, Rocio Acuna-Hidalgo, Derek Reid, Kristin Sikkink, Monika Mauermann, Edwin F. Juarez, Anne Jenseit, James T. Robinson, Kristian W. Pajtler, Till Milde, Natalie Jäger, Petra Fiesel, Ling Morgan, Sunita Sridhar, Nicole G. Coufal, Michael Levy, Denise Malicki, Charlotte Hobbs, Stephen Kingsmore, Shareef Nahas, Matija Snuderl, John Crawford, Robert J. Wechsler-Reya, Tom Belle Davidson, Jennifer Cotter, George Michaiel, Gudrun Fleischhack, Stefan Mundlos, Anthony Schmitt, Hannah Carter, Kulandaimanuvel Antony Michealraj, Sachin A. Kumar, Michael D. Taylor, Jeremy Rich, Frank Buchholz, Jill P. Mesirov, Stefan M. Pfister, Ferhat Ay, Jesse R. Dixon, Marcel Kool & Lukas Chavez |
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| E-Jahr: | 2023 |
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| Jahr: | 21 April 2023 |
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| Umfang: | 16 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 21. April 2023 ; Gesehen am 12.12.2023 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 14(2023), Artikel-ID 2300, Seite 1-16 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Ependymoma is a tumor of the brain or spinal cord. The two most common and aggressive molecular groups of ependymoma are the supratentorial ZFTA-fusion associated and the posterior fossa ependymoma group A. In both groups, tumors occur mainly in young children and frequently recur after treatment. Although molecular mechanisms underlying these diseases have recently been uncovered, they remain difficult to target and innovative therapeutic approaches are urgently needed. Here, we use genome-wide chromosome conformation capture (Hi-C), complemented with CTCF and H3K27ac ChIP-seq, as well as gene expression and DNA methylation analysis in primary and relapsed ependymoma tumors, to identify chromosomal conformations and regulatory mechanisms associated with aberrant gene expression. In particular, we observe the formation of new topologically associating domains (‘neo-TADs’) caused by structural variants, group-specific 3D chromatin loops, and the replacement of CTCF insulators by DNA hyper-methylation. Through inhibition experiments, we validate that genes implicated by these 3D genome conformations are essential for the survival of patient-derived ependymoma models in a group-specific manner. Thus, this study extends our ability to reveal tumor-dependency genes by 3D genome conformations even in tumors that lack targetable genetic alterations. |
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| DOI: | doi:10.1038/s41467-023-38044-0 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41467-023-38044-0 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-023-38044-0 |
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| | DOI: https://doi.org/10.1038/s41467-023-38044-0 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer genomics |
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| | CNS cancer |
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| K10plus-PPN: | 1873111304 |
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| Verknüpfungen: | → Zeitschrift |
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3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma / Okonechnikov, Konstantin [VerfasserIn]; 21 April 2023 (Online-Ressource)
