| |  Online-Ressource |
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| Verfasst von: | Selaskowski, Benjamin [VerfasserIn]  |
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| | Staerk, Christian [VerfasserIn] |
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| | Braun, Niclas [VerfasserIn] |
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| | Matthies, Swantje [VerfasserIn] |
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| | Graf, Erika [VerfasserIn] |
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| | Colla, Michael [VerfasserIn] |
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| | Jacob, Christian [VerfasserIn] |
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| | Sobanski, Esther [VerfasserIn] |
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| | Alm, Barbara [VerfasserIn] |
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| | Roesler, Michael [VerfasserIn] |
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| | Retz, Wolfgang [VerfasserIn] |
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| | Retz-Junginger, Petra [VerfasserIn] |
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| | Kis, Bernhard [VerfasserIn] |
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| | Abdel-Hamid, Mona [VerfasserIn] |
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| | Huss, Michael [VerfasserIn] |
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| | Jans, Thomas [VerfasserIn] |
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| | Tebartz van Elst, Ludger [VerfasserIn] |
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| | Berger, Mathias [VerfasserIn] |
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| | Lux, Silke [VerfasserIn] |
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| | Mayr, Andreas [VerfasserIn] |
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| | Philipsen, Alexandra [VerfasserIn] |
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| Titel: | Multimodal treatment efficacy differs in dependence of core symptom profiles in adult Attention-Deficit/Hyperactivity Disorder |
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| Titelzusatz: | an analysis of the randomized controlled COMPAS trial |
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| Verf.angabe: | Benjamin Selaskowski, Christian Staerk, Niclas Braun, Swantje Matthies, Erika Graf, Michael Colla, Christian Jacob, Esther Sobanski, Barbara Alm, Michael Roesler, Wolfgang Retz, Petra Retz-Junginger, Bernhard Kis, Mona Abdel-Hamid, Michael Huss, Thomas Jans, Ludger Tebartz van Elst, Mathias Berger, Silke Lux, Andreas Mayr, Alexandra Philipsen |
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| E-Jahr: | 2022 |
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| Jahr: | July 2022 |
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| Umfang: | 10 S. |
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| Fussnoten: | Online verfügbar: 1 April 2022, Artikelversion: 29 April 2022 ; Gesehen am 12.12.2023 |
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| Titel Quelle: | Enthalten in: Journal of psychiatric research |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1961 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 151(2022) vom: Juli, Seite 225-234 |
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| ISSN Quelle: | 1879-1379 |
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| Abstract: | There is broad consensus that to improve the treatment of adult Attention-Deficit/Hyperactivity Disorder (ADHD), the various therapy options need to be tailored more precisely to the individual patient's needs and specific symptoms. This post-hoc analysis evaluates the multimodal effects of first-line medication (methylphenidate [MPH] vs placebo [PLB]) and psychotherapeutic (group psychotherapy [GPT] vs clinical management [CM]) treatments on the ADHD core symptoms inattention, hyperactivity and impulsivity. For the two-by-two factorial, observer-blinded, multicenter, randomized controlled Comparison of Methylphenidate and Psychotherapy in Adult ADHD Study (COMPAS; ISRCTN54096201), 419 outpatients with ADHD were considered for analysis. ADHD symptoms were assessed by blind observer-rated and patient-rated Conners Adult ADHD Rating Scales before treatment (T1), 13 weeks (T2) and 26 weeks (T3) after T1, at treatment completion after 52 weeks (T4), and at follow-up (130 weeks, T5). MPH was superior to PLB in improving symptoms of inattention at almost all endpoints (observer-rated T2, T3, T4, T5; patient-rated T2, T3, T4), while a significant decrease in hyperactivity and impulsivity was at first found after 6 months of treatment. CM compared to GPT decreased inattention and impulsivity in the early treatment phase only (observer-rated T2, patient-rated T2, T3). In conclusion, while MPH seems to have a direct and sustained effect on inattention, premature medication discontinuation should particularly be avoided in patients with hyperactive-impulsive symptoms. Also, especially in high inattention and/or impulsivity presentations, initial individual patient management might be beneficial. Consequently, considering individual core symptom profiles may enhance the efficacy of treatments in adult ADHD. |
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| DOI: | doi:10.1016/j.jpsychires.2022.03.049 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jpsychires.2022.03.049 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0022395622001789 |
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| | DOI: https://doi.org/10.1016/j.jpsychires.2022.03.049 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ADHD subtype presentations |
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| | Adults |
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| | Attention-deficit/hyperactivity disorder |
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| | Core symptoms |
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| | Methylphenidate |
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| | Psychotherapy |
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| K10plus-PPN: | 1873162863 |
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| Verknüpfungen: | → Zeitschrift |
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Multimodal treatment efficacy differs in dependence of core symptom profiles in adult Attention-Deficit/Hyperactivity Disorder / Selaskowski, Benjamin [VerfasserIn]; July 2022 (Online-Ressource)
