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Status: Bibliographieeintrag

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Verfasst von:Ose, Jennifer [VerfasserIn]   i
 Gigić, Biljana [VerfasserIn]   i
 Brezina, Stefanie [VerfasserIn]   i
 Lin, Tengda [VerfasserIn]   i
 Peoples, Anita R. [VerfasserIn]   i
 Schobert, Pauline P. [VerfasserIn]   i
 Baierl, Andreas [VerfasserIn]   i
 van Roekel, Eline [VerfasserIn]   i
 Robinot, Nivonirina [VerfasserIn]   i
 Gicquiau, Audrey [VerfasserIn]   i
 Achaintre, David [VerfasserIn]   i
 Scalbert, Augustin [VerfasserIn]   i
 van Duijnhoven, Fränzel J. B. [VerfasserIn]   i
 Holowatyj, Andreana N. [VerfasserIn]   i
 Gumpenberger, Tanja [VerfasserIn]   i
 Schrotz-King, Petra [VerfasserIn]   i
 Ulrich, Alexis [VerfasserIn]   i
 Ulvik, Arve [VerfasserIn]   i
 Ueland, Per-Magne [VerfasserIn]   i
 Weijenberg, Matty P. [VerfasserIn]   i
 Habermann, Nina [VerfasserIn]   i
 Keski-Rahkonen, Pekka [VerfasserIn]   i
 Gsur, Andrea [VerfasserIn]   i
 Kok, Dieuwertje E. G. [VerfasserIn]   i
 Ulrich, Cornelia [VerfasserIn]   i
Titel:Higher plasma creatinine is associated with an increased risk of death in patients with non-metastatic rectal but not colon cancer
Titelzusatz:results from an international cohort consortium
Verf.angabe:Jennifer Ose, Biljana Gigic, Stefanie Brezina, Tengda Lin, Anita R. Peoples, Pauline P. Schobert, Andreas Baierl, Eline van Roekel, Nivonirina Robinot, Audrey Gicquiau, David Achaintre, Augustin Scalbert, Fränzel J.B. van Duijnhoven, Andreana N. Holowatyj, Tanja Gumpenberger, Petra Schrotz-King, Alexis B. Ulrich, Arve Ulvik, Per-Magne Ueland, Matty P. Weijenberg, Nina Habermann, Pekka Keski-Rahkonen, Andrea Gsur, Dieuwertje E. Kok and Cornelia M. Ulrich
E-Jahr:2023
Jahr:28 June 2023
Umfang:15 S.
Fussnoten:Gesehen am 12.12.2023
Titel Quelle:Enthalten in: Cancers
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2023
Band/Heft Quelle:15(2023), 13, Artikel-ID 3391, Seite 1-15
ISSN Quelle:2072-6694
Abstract:Colorectal cancer (CRC) is increasingly recognized as a heterogeneous disease. No studies have prospectively examined associations of blood metabolite concentrations with all-cause mortality in patients with colon and rectal cancer separately. Targeted metabolomics (Biocrates AbsoluteIDQ p180) and pathway analyses (MetaboAnalyst 4.0) were performed on pre-surgery collected plasma from 674 patients with non-metastasized (stage I-III) colon (n = 394) or rectal cancer (n = 283). Metabolomics data and covariate information were received from the international cohort consortium MetaboCCC. Cox proportional hazards models were computed to investigate associations of 148 metabolite levels with all-cause mortality adjusted for age, sex, tumor stage, tumor site (whenever applicable), and cohort; the false discovery rate (FDR) was used to account for multiple testing. A total of 93 patients (14%) were deceased after an average follow-up time of 4.4 years (60 patients with colon cancer and 33 patients with rectal cancer). After FDR adjustment, higher plasma creatinine was associated with a 39% increase in all-cause mortality in patients with rectal cancer. HR: 1.39, 95% CI 1.23-1.72, pFDR = 0.03; but not colon cancer: pFDR = 0.96. Creatinine is a breakdown product of creatine phosphate in muscle and may reflect changes in skeletal muscle mass. The starch and sucrose metabolisms were associated with increased all-cause mortality in colon cancer but not in rectal cancer. Genes in the starch and sucrose metabolism pathways were previously linked to worse clinical outcomes in CRC. In summary, our findings support the hypothesis that colon and rectal cancer have different etiological and clinical outcomes that need to be considered for targeted treatments.
DOI:doi:10.3390/cancers15133391
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/cancers15133391
 kostenfrei: Volltext: https://www.mdpi.com/2072-6694/15/13/3391
 DOI: https://doi.org/10.3390/cancers15133391
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:all-cause mortality
 colon cancer
 creatinine
 metabolites
 rectal cancer
 starch and sucrose pathway
K10plus-PPN:1873171552
Verknüpfungen:→ Zeitschrift

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