Coffee intake, caffeine metabolism genotype, and survival among men with prostate cancer

• Verfasst von: Gregg, Justin R. [VerfasserIn]
• Verfasst von: Kim, Jeri [VerfasserIn]
• Verfasst von: Logothetis, Christopher [VerfasserIn]
• Verfasst von: Hanash, Sam [VerfasserIn]
• Verfasst von: Zhang, Xiaotao [VerfasserIn]
• Verfasst von: Manyam, Ganiraju [VerfasserIn]
• Verfasst von: Muir, Kenneth [VerfasserIn]
• Verfasst von: Giles, Graham G. [VerfasserIn]
• Verfasst von: Stanford, Janet L. [VerfasserIn]
• Verfasst von: Berndt, Sonja I. [VerfasserIn]
• Verfasst von: Kogevinas, Manolis [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Verfasst von: Eeles, Rosalind A. [VerfasserIn]
• Verfasst von: Wei, Peng [VerfasserIn]
• Verfasst von: Daniel, Carrie R. [VerfasserIn]
• Titel: Coffee intake, caffeine metabolism genotype, and survival among men with prostate cancer
• Verf.angabe: Justin R. Gregg, Jeri Kim, Christopher Logothetis, Sam Hanash, Xiaotao Zhang, Ganiraju Manyam, Kenneth Muir, UKGPCS Collaborative Group, Graham G. Giles, Janet L. Stanford, Sonja I. Berndt, Manolis Kogevinas, Hermann Brenner, Rosalind A. Eeles, PRACTICAL Consortium, Peng Wei, Carrie R. Daniel
• E-Jahr: 2023
• Jahr: 20 August 2022
• Umfang: 7 S.
• Fussnoten: Online veröffentlicht: 20. August 2022, Version der Publikation: 14. Juni 2023 ; Gesehen am 12.12.2023
• Titel Quelle: Enthalten in: European urology oncology
• Ort Quelle: Amsterdam : Elsevier, 2018
• Jahr Quelle: 2023
• Band/Heft Quelle: 6(2023), 3, Seite 282-288
• ISSN Quelle: 2588-9311
• DOI: doi:10.1016/j.euo.2022.07.008
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Caffeine
• Sach-SW: Coffee
• Sach-SW: Genetic variation
• Sach-SW: Mortality
• Sach-SW: Prostatic neoplasms
• K10plus-PPN: 1873176341

Abstract

Background - Coffee intake may lower prostate cancer risk and progression, but postdiagnosis outcomes by caffeine metabolism genotype are not well characterized. - Objective - To evaluate associations between coffee intake, caffeine metabolism genotype, and survival in a large, multicenter study of men with prostate cancer. - Design, setting, and participants - Data from The PRACTICAL Consortium database for 5727 men with prostate cancer from seven US, Australian, and European studies were included. The cases included had data available for the CYP1A2 −163C>A rs762551 single-nucleotide variant associated with caffeine metabolism, coffee intake, and >6 mo of follow-up. - Outcome measurements and statistical analysis - Multivariable-adjusted Cox proportional hazards models across pooled patient-level data were used to compare the effect of coffee intake (categorized as low [reference], high, or none/very low) in relation to overall survival (OS) and prostate cancer-specific survival (PCSS), with stratified analyses conducted by clinical disease risk and genotype. - Results and limitations - High coffee intake appeared to be associated with longer PCSS (hazard ratio [HR] 0.85, 95% confidence interval [CI] 0.68-1.08; p = 0.18) and OS (HR 0.90, 95% CI 0.77-1.07; p = 0.24), although results were not statistically significant. In the group with clinically localized disease, high coffee intake was associated with longer PCSS (HR 0.66, 95% CI 0.44-0.98; p = 0.040), with comparable results for the group with advanced disease (HR 0.92, 95% CI 0.69-1.23; p = 0.6). High coffee intake was associated with longer PCSS among men with the CYP1A2 AA (HR 0.67, 95% CI 0.49-0.93; p = 0.017) but not the AC/CC genotype (p = 0.8); an interaction was detected (p = 0.042). No associations with OS were observed in subgroup analyses (p > 0.05). Limitations include the nominal statistical significance and residual confounding. - Conclusions - Coffee intake was associated with longer PCSS among men with a CYP1A2 −163AA (*1F/*1F) genotype, a finding that will require further replication. - Patient summary - It is likely that coffee intake is associated with longer prostate cancer-specific survival in certain groups, but more research is needed to fully understand which men may benefit and why.