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Verfasst von:Enzmann, Harald G. [VerfasserIn]   i
 Kühlem, Christiane [VerfasserIn]   i
 Kaliner, Georg [VerfasserIn]   i
 Löser, Eckhard [VerfasserIn]   i
 Bannasch, Peter [VerfasserIn]   i
Titel:Rapid induction of preneoplastic liver foci in embryonal turkey liver by diethylnitrosamine
Verf.angabe:Harald Enzmann, Christiane Kühlem, Georg Kaliner, Eckhard Löser, Peter Bannasch
Jahr:1995
Umfang:10 S.
Fussnoten:Gesehen am 13.12.2023
Titel Quelle:Enthalten in: Toxicologic pathology
Ort Quelle:Thousand Oaks, Calif. : Sage, 1978
Jahr Quelle:1995
Band/Heft Quelle:23(1995), 5, Seite 560-569
ISSN Quelle:1533-1601
Abstract:Diethylnitrosamine (DEN) was injected into fertilized turkey eggs. After incubation for 24 days, the livers of the embryos were removed and investigated by means of histological and enzyme-histochemical methods. Doses of 2 and 5 mg DEN per egg had no effect on mortality and embryo weight but induced various types of foci of altered hepatocytes. In addition, a replacement of the trabecular structure of the liver by a tubular arrangement of the hepatocytes and markedly enlarged hepatocytes were found. The diethylnitrosamine-induced foci of altered hepatocytes were very similar to the preneoplastic lesions that occur in the liver of mammals during hepatocarcinogenesis and are regarded as early indicators of carcinogenicity. The presented in ovo model is a simple (1 dose), rapid (24 days), and inexpensive (no animal housing) approach for the induction of foci of altered hepatocytes. The sensitivity of this carcinogenesis bioassay appears to be comparable to that of lifetime studies in rodents. It is proposed that the induction of preneoplastic foci of altered hepatocytes in ovo is a valuable screening model for hepatocarcinogenic effects.
DOI:doi:10.1177/019262339502300502
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1177/019262339502300502
 DOI: https://doi.org/10.1177/019262339502300502
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1874656797
Verknüpfungen:→ Zeitschrift

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