| |  Online-Ressource |
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| Verfasst von: | McLean, Thomas W. [VerfasserIn]  |
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| | Ringold, Sarah [VerfasserIn] |
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| | Neuberg, Donna [VerfasserIn] |
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| | Stegmaier, Kimberly [VerfasserIn] |
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| | Tantravahi, Ramana [VerfasserIn] |
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| | Ritz, Jerome [VerfasserIn] |
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| | Koeffler, H. Phillip [VerfasserIn] |
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| | Takeuchi, Seisho [VerfasserIn] |
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| | Janssen, Johannes W. G. [VerfasserIn] |
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| | Seriu, Taku [VerfasserIn] |
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| | Bartram, Claus R. [VerfasserIn] |
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| | Sallan, Stephen E. [VerfasserIn] |
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| | Gilliland, D. Gary [VerfasserIn] |
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| | Golub, Todd R. [VerfasserIn] |
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| Titel: | TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia |
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| Verf.angabe: | Thomas W. McLean, Sarah Ringold, Donna Neuberg, Kimberly Stegmaier, Ramana Tantravahi, Jerome Ritz, H. Phillip Koeffler, Seisho Takeuchi, Johannes W. G. Janssen, Taku Seriu, Claus R. Bartram, Stephen E. Sallan, D. Gary Gilliland, Todd R. Golub |
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| E-Jahr: | 1996 |
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| Jahr: | 1 December 1996 |
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| Umfang: | 7 S. |
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| Fussnoten: | Elektronische Reproduktion der Druck-Ausgabe 14. Dezember 2020 ; Gesehen am 14.12.2023 |
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| Titel Quelle: | Enthalten in: Blood |
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| Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
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| Jahr Quelle: | 1996 |
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| Band/Heft Quelle: | 88(1996), 11, Seite 4252-4258 |
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| ISSN Quelle: | 1528-0020 |
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| Abstract: | Polymerase chain reaction-based screening of childhood acute lymphoblastic leukemia (ALL) samples showed that a TEL/AML 1 fusion transcript was detected in 27% of all cases, representing the most common known gene rearrangement in childhood cancer. The TEL/AML1 fusion results from a t(12;21)(p13;q22) chromosomal translocation, but was undetectable at the routine cytogenetic level. TEL/AML1-positive patients had exclusively B-lineage ALL, and most patients were between the ages of 2 and 9 years at diagnosis. Only 3/89 (3.4%) adult ALL patients were TEL/AML 7-positive. Most importantly, TEL/AML 1-positive children had a significantly lower rate of relapse compared with TEL/AML 1-negative patients (0/22 ν 16/54, P = .004). Co-immunoprecipitation experiments demonstrated that TEL/AML-1 formed homodimers in vitro, and heterodimerized with the normal TEL protein when the two proteins were expressed together. The elucidation of the precise mechanism of transformation by TEL/AML1 and the role of TEL/AML1 testing in the treatment of childhood ALL will require additional studies. |
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| DOI: | doi:10.1182/blood.V88.11.4252.4252 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood.V88.11.4252.4252 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0006497120611703 |
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| | DOI: https://doi.org/10.1182/blood.V88.11.4252.4252 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1874817898 |
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| Verknüpfungen: | → Zeitschrift |
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TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia / McLean, Thomas W. [VerfasserIn]; 1 December 1996 (Online-Ressource)
