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Verfasst von:Tan, Benjamin [VerfasserIn]   i
 Schütte, Isabel [VerfasserIn]   i
 Engel, Michael [VerfasserIn]   i
 Bruckner, Thomas [VerfasserIn]   i
 Weigand, Markus A. [VerfasserIn]   i
 Busch, Cornelius [VerfasserIn]   i
Titel:Comparison of fluid replacement with Sterofundin ISO® vs. Deltajonin® in infants undergoing craniofacial surgery - a retrospective study
Verf.angabe:Benjamin Tan, Isabel Schütte, Michael Engel, Thomas Bruckner, Markus A. Weigand and Cornelius J. Busch
E-Jahr:2023
Jahr:8 October 2023
Umfang:12 S.
Illustrationen:Illustrationen
Fussnoten:Veröffentlicht: 8. Oktober 2023 ; Gesehen am 14.12.2023
Titel Quelle:Enthalten in: Journal of Clinical Medicine
Ort Quelle:Basel : MDPI, 2012
Jahr Quelle:2023
Band/Heft Quelle:12(2023), 19, Artikel-ID 6404, Seite 1-12
ISSN Quelle:2077-0383
Abstract:In recent decades, infusion solutions such as NaCl 0.9% and lactate Ringer’s solution have been replaced in clinical practice. Since 2017, the national guidelines for perioperative infusion therapy in children recommend balanced isotonic solutions to maintain fluid balance. The composition of balanced infusion solutions varies with respect to their electrolyte content. Hyperchloremia may be mistaken for hypovolemia and may interfere with volume therapy in pediatric patients. Sterofundin ISO® balanced solution contains 127 mmol/L chloride and may cause hyperchloremic acidosis if administered in large volumes. Objectives: The purpose of this study was to compare the effects of Sterofundin ISO® (SF) therapy with the balanced isochloremic solution Deltajonin® (DJ) (106 mmol/L chloride) on the acid-base status in infants undergoing craniofacial surgery. Methods: This retrospective, non-blinded study included 100 infants undergoing craniectomy due to isolated nonsyndromic sagittal craniosynostosis. The first 50 infants received Sterofundin ISO®. Due to changes in national guidelines, the infusion was changed to the isoionic Deltajonin® in an additional 50 infants in 2017. Pre- and postoperative values of chloride, pH, base excess, bicarbonate, and albumin and phosphate were determined, and the strong-ion difference, strong-ion gap, anion gap, and weak acids were calculated. Results: Both groups were comparable in terms of their age, sex, underlying disease, preoperative electrolytes (except K at 3.9 ± 0.3 mmol/L (SF) vs. 4.1 ± 0.3 mmol/L (DJ) and lactate 8.7 ± 2.1 (SF) vs. 9.6 ± 2.6 mmol/L (DJ)). In the Sterofundin ISO® group, hyperchloremic metabolic acidosis was observed in 19 patients, whereas only 2 infants in the Deltajonin® group had hyperchloremic metabolic acidosis. The postoperative chloride level was 111 ± 2.7 mmol/L (SF) vs. 108 ± 2.4 mmol/L (DJ). The difference in anion gap was 12.5 ± 3.0 mmol/L (SF) vs. 14.6 ± 2.8 mmol/L (DJ), and the difference in SIDa (apparent strong-ion difference) was 30.9 mmol/L (SF) vs. 33.8 mmol/L (DJ). Conclusions: Hyperchloremic acidosis can be induced by the volume replacement with high-chloride-concentration crystalloids such as Sterofundin ISO®. This can be detected using the Stewart model.
DOI:doi:10.3390/jcm12196404
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/jcm12196404
 kostenfrei: Volltext: https://www.mdpi.com/2077-0383/12/19/6404
 DOI: https://doi.org/10.3390/jcm12196404
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:craniectomy
 hyperchloremia
 isochloremic solution
K10plus-PPN:1875571175
Verknüpfungen:→ Zeitschrift

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