| Online-Ressource |
Verfasst von: | Requena, Gema [VerfasserIn]  |
| Czira, Alexandrosz [VerfasserIn]  |
| Banks, Victoria [VerfasserIn]  |
| Wood, Robert [VerfasserIn]  |
| Tritton, Theo [VerfasserIn]  |
| Castillo, Catherine [VerfasserIn]  |
| Yeap, Jie [VerfasserIn]  |
| Wild, Rosie [VerfasserIn]  |
| Compton, Chris [VerfasserIn]  |
| Rothnie, Kieran J. [VerfasserIn]  |
| Herth, Felix [VerfasserIn]  |
| Quint, Jennifer [VerfasserIn]  |
| Ismaila, Afisi S. [VerfasserIn]  |
Titel: | Comparative effectiveness of umeclidinium/vilanterol versus indacaterol/glycopyrronium on Moderate-to-severe exacerbations in patients with chronic obstructive pulmonary disease in clinical practice in England |
Verf.angabe: | Gema Requena, Alexandrosz Czira, Victoria Banks, Robert Wood, Theo Tritton, Catherine Castillo, Jie Yeap, Rosie Wild, Chris Compton, Kieran J. Rothnie, Felix Herth, Jennifer Quint, Afisi S. Ismaila |
E-Jahr: | 2023 |
Jahr: | 15 September 2023 |
Umfang: | 16 S. |
Fussnoten: | Gesehen am 18.12.2023 |
Titel Quelle: | Enthalten in: The International journal of chronic obstructive pulmonary disease |
Ort Quelle: | Albany, Auckland : DOVE Medical Press, 2006 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | Volume 18(2023), Seite 2039-2054 |
ISSN Quelle: | 1178-2005 |
Abstract: | Purpose: Chronic obstructive pulmonary disease (COPD) exacerbations are associated with significant morbidity and mortality and increased economic healthcare burden for patients with COPD. Long-acting muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA) dual therapy is recommended for patients receiving mono-bronchodilator therapy who experience exacerbations or ongoing breathlessness. This study compared two single-inhaler LAMA/LABA dual therapies, umeclidinium/vilanterol (UMEC/VI) and indacaterol/glycopyrronium (IND/GLY), on moderate-to-severe exacerbation rates in patients with COPD in England. Patients and Methods: This retrospective cohort study used linked primary care electronic health record data (Clinical Practice Research Datalink-Aurum) and secondary care data (Hospital Episode Statistics) to assess outcomes for patients with COPD who had a first prescription for single-inhaler UMEC/VI or IND/GLY (index date) between 1 January 2015 and 30 September 2019 (indexing period). Analyses compared UMEC/VI and IND/GLY on moderate-to-severe, moderate, and severe exacerbations, healthcare resource utilization (HCRU), and direct costs at 6, 12, 18, and 24 months, and time-to-first on-treatment exacerbation up to 24 months postindex date. Following inverse probability of treatment weighting (IPTW), non-inferiority and superiority of UMEC/VI versus IND/GLY were assessed. - Results: In total, 12,031 patients were included, of whom 8753 (72.8%) were prescribed UMEC/VI and 3278 (27.2%) IND/GLY. After IPTW, for moderate-to-severe exacerbations, weighted rate ratios were <1 at 6, 12, and 18 months and equal to 1 at 24 months for UMEC/VI; around the null value for moderate exacerbations and <1 at all timepoints for severe exacerbations. UMEC/VI showed lower HCRU incidence rates than IND/GLY for all-cause Accident and Emergency visits and COPD-related inpatient stays and associated all-cause costs at 6 months post-indexing. Time-to-triple therapy was similar for both treatments. - Conclusion: UMEC/VI demonstrated non-inferiority to IND/GLY in moderate-to-severe exacerbation reduction at 6, 12 and 18 months. These results support previous findings demonstrating similarity between UMEC/VI and IND/GLY on reduction of moderateto-severe exacerbations. |
DOI: | doi:10.2147/COPD.S408688 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.2147/COPD.S408688 |
| Volltext: https://www.dovepress.com/comparative-effectiveness-of-umeclidiniumvilanterol-versus-indacaterol-peer-reviewed-fulltext- ... |
| DOI: https://doi.org/10.2147/COPD.S408688 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1876281448 |
Verknüpfungen: | → Zeitschrift |
Comparative effectiveness of umeclidinium/vilanterol versus indacaterol/glycopyrronium on Moderate-to-severe exacerbations in patients with chronic obstructive pulmonary disease in clinical practice in England / Requena, Gema [VerfasserIn]; 15 September 2023 (Online-Ressource)