Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Tanasić, Dajana [VerfasserIn]  |
| Berns, Nicola [VerfasserIn]  |
| Riechmann, Veit [VerfasserIn]  |
Titel: | Myosin V facilitates polarised E-cadherin secretion |
Verf.angabe: | Dajana Tanasic, Nicola Berns, Veit Riechmann |
E-Jahr: | 2022 |
Jahr: | July 2022 |
Umfang: | 17 S. |
Illustrationen: | Illustrationen |
Fussnoten: | First published: 16 May 2022 ; Gesehen am 19.12.2023 |
Titel Quelle: | Enthalten in: Traffic |
Ort Quelle: | Oxford : Wiley-Blackwell, 2000 |
Jahr Quelle: | 2022 |
Band/Heft Quelle: | 23(2022), 7 vom: Juli, Seite 374-390 |
ISSN Quelle: | 1600-0854 |
Abstract: | E-cadherin has a fundamental role in epithelial tissues by providing cell-cell adhesion. Polarised E-cadherin exocytosis to the lateral plasma membrane is central for cell polarity and epithelial homeostasis. Loss of E-cadherin secretion compromises tissue integrity and is a prerequisite for metastasis. Despite this pivotal role of E-cadherin secretion, the transport mechanism is still unknown. Here we identify Myosin V as the motor for E-cadherin secretion. Our data reveal that Myosin V and F-actin are required for the formation of a continuous apicolateral E-cadherin belt, the zonula adherens. We show by live imaging how Myosin V transports E-cadherin vesicles to the plasma membrane, and distinguish two distinct transport tracks: an apical actin network leading to the zonula adherens and parallel actin bundles leading to the basal-most region of the lateral membrane. E-cadherin secretion starts in endosomes, where Rab11 and Sec15 recruit Myosin V for transport to the zonula adherens. We also shed light on the endosomal sorting of E-cadherin by showing how Rab7 and Snx16 cooperate in moving E-cadherin into the Rab11 compartment. Thus, our data help to understand how polarised E-cadherin secretion maintains epithelial architecture and prevents metastasis. |
DOI: | doi:10.1111/tra.12846 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1111/tra.12846 |
| kostenfrei: Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/tra.12846 |
| DOI: https://doi.org/10.1111/tra.12846 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | E-cadherin |
| Myosin V |
| Rab11 |
| Rab7 |
| SNX16 |
K10plus-PPN: | 1876370254 |
Verknüpfungen: | → Zeitschrift |
Myosin V facilitates polarised E-cadherin secretion / Tanasić, Dajana [VerfasserIn]; July 2022 (Online-Ressource)
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