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Status: Bibliographieeintrag

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Verfasst von:Tulessin, Margaret [VerfasserIn]   i
 Sarker, Rim Sabrina Jahan [VerfasserIn]   i
 Griger, Joscha [VerfasserIn]   i
 Leibing, Thomas [VerfasserIn]   i
 Géraud, Cyrill [VerfasserIn]   i
 Weichert, Wilko [VerfasserIn]   i
 Steiger, Katja [VerfasserIn]   i
 Mogler, Carolin [VerfasserIn]   i
Titel:Vascular remodeling is a crucial event in the early phase of hepatocarcinogenesis in rodent models for liver tumorigenesis
Verf.angabe:Margaret Tulessin, Rim Sabrina Jahan Sarker, Joscha Griger, Thomas Leibing, Cyrill Geraud, Wilko Weichert, Katja Steiger and Carolin Mogler
E-Jahr:2022
Jahr:6 July 2022
Umfang:15 S.
Fussnoten:Gesehen am 19.12.2023
Titel Quelle:Enthalten in: Cells
Ort Quelle:Basel : MDPI, 2012
Jahr Quelle:2022
Band/Heft Quelle:11(2022), 14, Artikel-ID 2129, Seite 1-15
ISSN Quelle:2073-4409
Abstract:The investigation of hepatocarcinogenesis is a major field of interest in oncology research and rodent models are commonly used to unravel the pathophysiology of onset and progression of hepatocellular carcinoma. HCC is a highly vascularized tumor and vascular remodeling is one of the hallmarks of tumor progression. To date, only a few detailed data exist about the vasculature and vascular remodeling in rodent models used for hepatocarcinogenesis. In this study, the vasculature of HCC and the preneoplastic foci of alteration (FCA) of different mouse models with varying genetic backgrounds were comprehensively characterized by using immunohistochemistry (CD31, Collagen IV, αSMA, Desmin and LYVE1) and RNA in situ hybridization (VEGF-A). Computational image analysis was performed to evaluate selected parameters including microvessel density, pericyte coverage, vessel size, intratumoral vessel distribution and architecture using the Aperio ImageScope and Definiens software programs. HCC presented with a significantly lower number of vessels, but larger vessel size and increased coverage, leading to a higher degree of maturation, whereas FCA lesions presented with a higher microvessel density and a higher amount of smaller but more immature vessels. Our results clearly demonstrate that vascular remodeling is present and crucial in early stages of experimental hepatocarcinogenesis. In addition, our detailed characterization provides a strong basis for further angiogenesis studies in these experimental models.
DOI:doi:10.3390/cells11142129
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/cells11142129
 kostenfrei: Volltext: https://www.mdpi.com/2073-4409/11/14/2129
 DOI: https://doi.org/10.3390/cells11142129
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:animal model
 foci of cellular alteration
 hepatocellular carcinoma
 image analysis
 vascular remodeling
 vessel analysis
K10plus-PPN:1876374500
Verknüpfungen:→ Zeitschrift

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