Enablers and challenges of spatial omics, a melting pot of technologies

• Verfasst von: Alexandrov, Theodore [VerfasserIn]
• Verfasst von: Sáez Rodríguez, Julio [VerfasserIn]
• Verfasst von: Saka, Sinem [VerfasserIn]
• Titel: Enablers and challenges of spatial omics, a melting pot of technologies
• Verf.angabe: Theodore Alexandrov, Julio Saez‐Rodriguez & Sinem K Saka
• E-Jahr: 2023
• Jahr: Nov 2023
• Umfang: 16 S.
• Illustrationen: Illustrationen
• Fussnoten: Online veröffentlicht: 16. Oktober 2023 ; Gesehen am 20.12.2023
• Titel Quelle: Enthalten in: Molecular systems biology
• Ort Quelle: [London] : Nature Publishing Group UK, 2005
• Jahr Quelle: 2023
• Band/Heft Quelle: 19(2023), 11 vom: Nov., Artikel-ID e10571, Seite 1-16
• ISSN Quelle: 1744-4292
• DOI: doi:10.15252/msb.202110571
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: genomics
• Sach-SW: metabolomics
• Sach-SW: proteomics
• Sach-SW: spatial omics
• Sach-SW: transcriptomics
• K10plus-PPN: 1876525681

Abstract

Spatial omics has emerged as a rapidly growing and fruitful field with hundreds of publications presenting novel methods for obtaining spatially resolved information for any omics data type on spatial scales ranging from subcellular to organismal. From a technology development perspective, spatial omics is a highly interdisciplinary field that integrates imaging and omics, spatial and molecular analyses, sequencing and mass spectrometry, and image analysis and bioinformatics. The emergence of this field has not only opened a window into spatial biology, but also created multiple novel opportunities, questions, and challenges for method developers. Here, we provide the perspective of technology developers on what makes the spatial omics field unique. After providing a brief overview of the state of the art, we discuss technological enablers and challenges and present our vision about the future applications and impact of this melting pot.