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Status: Bibliographieeintrag

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Verfasst von:Voss, Philipp A. [VerfasserIn]   i
 Gornik, Sebastian G. [VerfasserIn]   i
 Jacobovitz, Marie [VerfasserIn]   i
 Rupp, Sebastian [VerfasserIn]   i
 Dörr, Melanie [VerfasserIn]   i
 Mägele, Ira [VerfasserIn]   i
 Guse, Annika [VerfasserIn]   i
Titel:Host nutrient sensing is mediated by mTOR signaling in cnidarian-dinoflagellate symbiosis
Verf.angabe:Philipp A. Voss, Sebastian G. Gornik, Marie R. Jacobovitz, Sebastian Rupp, Melanie Dörr, Ira Maegele, and Annika Guse
E-Jahr:2023
Jahr:11 September 2023
Umfang:20 S.
Fussnoten:Online verfügbar: 11. August 2023, Artikelversion: 11. September 2023 ; Gesehen am 03.01.2024
Titel Quelle:Enthalten in: Current biology
Ort Quelle:London : Current Biology Ltd., 1991
Jahr Quelle:2023
Band/Heft Quelle:33(2023), 17 vom: Nov., Seite 3634-3647.e5
ISSN Quelle:1879-0445
Abstract:To survive in the nutrient-poor waters of the tropics, reef-building corals rely on intracellular, photosynthetic dinoflagellate symbionts. Photosynthates produced by the symbiont are translocated to the host, and this enables corals to form the structural foundation of the most biodiverse of all marine ecosystems. Although the regulation of nutrient exchange between partners is critical for ecosystem stability and health, the mechanisms governing how nutrients are sensed, transferred, and integrated into host cell processes are largely unknown. Ubiquitous among eukaryotes, the mechanistic target of the rapamycin (mTOR) signaling pathway integrates intracellular and extracellular stimuli to influence cell growth and cell-cycle progression and to balance metabolic processes. A functional role of mTOR in the integration of host and symbiont was demonstrated in various nutritional symbioses, and a similar role of mTOR was proposed for coral-algal symbioses. Using the endosymbiosis model Aiptasia, we examined the role of mTOR signaling in both larvae and adult polyps across various stages of symbiosis. We found that symbiosis enhances cell proliferation, and using an Aiptasia-specific antibody, we localized mTOR to symbiosome membranes. We found that mTOR signaling is activated by symbiosis, while inhibition of mTOR signaling disrupts intracellular niche establishment and symbiosis altogether. Additionally, we observed that dysbiosis was a conserved response to mTOR inhibition in the larvae of a reef-building coral species. Our data confim that mTOR signaling plays a pivotal role in integrating symbiont-derived nutrients into host metabolism and symbiosis stability, ultimately allowing symbiotic cnidarians to thrive in challenging environments.
DOI:doi:10.1016/j.cub.2023.07.038
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.cub.2023.07.038
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0960982223009776
 DOI: https://doi.org/10.1016/j.cub.2023.07.038
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1877147001
Verknüpfungen:→ Zeitschrift

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