DNA adducts in urothelial cells

• Verfasst von: Vineis, Paolo [VerfasserIn]
• Verfasst von: Talaska, Glenn [VerfasserIn]
• Verfasst von: Malaveille, Christian [VerfasserIn]
• Verfasst von: Bartsch, Helmut [VerfasserIn]
• Verfasst von: Martone, Tiziana [VerfasserIn]
• Verfasst von: Sithisarankul, Pornchai [VerfasserIn]
• Verfasst von: Strickland, Paul [VerfasserIn]
• Titel: DNA adducts in urothelial cells
• Titelzusatz: relationship with biomarkers of exposure to arylamines and polycyclic aromatic hydrocarbons from tobacco smoke
• Verf.angabe: Paolo Vineis, Glenn Talaska, Christian Malaveille, Helmut Bartsch, Tiziana Martone, Pornchai Sithisarankul, Paul Strickland
• E-Jahr: 1996
• Jahr: 26 January 1996
• Umfang: 3 S.
• Fussnoten: Gesehen am 09.01.2024
• Titel Quelle: Enthalten in: International journal of cancer
• Ort Quelle: Bognor Regis : Wiley-Liss, 1966
• Jahr Quelle: 1996
• Band/Heft Quelle: 65(1996), 3, Seite 314-316
• ISSN Quelle: 1097-0215
• DOI: doi:10.1002/(SICI)1097-0215(19960126)65:3<314::AID-IJC6>3.0.CO;2-2
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1877497665

Abstract

Markers of exposure to polycyclic aromatic hydrocarbons (urinary 1-hydroxypyrene-glucuronide) and aromatic amines (4-aminobiphenyl-hemoglobin adducts), as well as urinary mutagenicity, were measured in 47 healthy smokers and 50 non-smokers. DNA adducts were determined by P32-postlabeling in the exfoliated bladder cells of 39 healthy subjects. Both 1-hydroxypyrene-glucuronide (1-OHPG) and 4-aminobiphenyl adducts (4-ABP-Hb) were associated with smoking habits, but only 4-ABP-Hb adducts were associated with consumption of black, air-cured tobacco. The levels of 2 DNA adducts (numbers 2 and 4) in urothelial cells were clearly associated with 4-ABP-Hb adducts, in all subjects and in smokers. Levels of one of these DNA adducts (number 2) were also associated with 1-hydroxypyrene-glucuronide in urines, but in smokers the association was not statistically significant. Overall, these observations constitute further evidence of a role of arylamines in tobacco-induced bladder cancer. © 1996 Wiley-Liss, Inc.