Real-time definition of single seed placement sensitivity in low-dose-rate prostate brachytherapy

• Verfasst von: Jerg, Katharina I. [VerfasserIn]
• Verfasst von: Okonkwo, Ernest Chukwudi N. [VerfasserIn]
• Verfasst von: Giordano, Frank Anton [VerfasserIn]
• Verfasst von: Abo-Madyan, Yasser [VerfasserIn]
• Verfasst von: Momm, Felix [VerfasserIn]
• Verfasst von: Hesser, Jürgen [VerfasserIn]
• Titel: Real-time definition of single seed placement sensitivity in low-dose-rate prostate brachytherapy
• Verf.angabe: Katharina I. Jerg, Ernest Chukwudi N. Okonkwo, Frank A. Giordano, Yasser Abo-Madyan, Felix Momm, Jürgen W. Hesser
• E-Jahr: 2023
• Jahr: 23 December 2023
• Umfang: 13 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 10.01.2024
• Titel Quelle: Enthalten in: Brachytherapy
• Ort Quelle: [Erscheinungsort nicht ermittelbar] : Elsevier, 2002
• Jahr Quelle: 2024
• Band/Heft Quelle: 23(2024), 2, Seite 224-236
• ISSN Quelle: 1873-1449
• DOI: doi:10.1016/j.brachy.2023.10.006
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Forschungsdaten: Jerg, Katharina I., 1992 - : Real-time definition of single seed placement sensitivity in low-dose-rate prostate brachytherapy [code and patient data]
• Sach-SW: Automatic differentiation
• Sach-SW: Dose objective
• Sach-SW: Low-dose-rate prostate brachytherapy
• Sach-SW: Seed placement
• Sach-SW: Sensitivity analysis
• K10plus-PPN: 1877625590

Abstract

PURPOSE: In low-dose-rate brachytherapy, iodine-125 seeds are implanted based on a treatment plan, generated with respect to different dose constraints. The quality of the dose distribution depends on a precise seed placement, however, during treatment planning the impact on the dose parameters when certain seeds fail to be placed precisely is not clear. METHODS AND MATERIALS: We developed a method using automatic differentiation to calculate gradients of dose parameters with regard to the seeds’ positions. Thus, we understand their sensitivity with respect to the seed placement. A statistical analysis is performed on a data set with 35 prostate brachytherapy patients. RESULTS: The most sensitive seeds regarding the dosimetric parameters of both rectum and urethra are close to the corresponding organ. Their gradient directions are mainly orthogonal to their surfaces. However, not all seeds close to the surface are equally sensitive with regard to the dose parameter. The most sensitive seeds regarding the prostate’s dose parameters are distributed throughout the prostate and the direction of the gradients are mainly parallel to its surface. A linear regression with respect to different patient parameters shows that dose constraints which are barely fulfilled have large gradients and thus are additionally sensitive to misplacement. CONCLUSION: Automatic differentiation can be used to analyze dose parameter sensitivity with respect to seed placement. Integrating this into treatment planning systems is valuable as it speeds up the planning procedure, making it more robust and less dependent on user experience while showing the operating physician which needle placements require greater accuracy than others.