Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Mielke, Emilia Louisa L. [VerfasserIn]   i
 Koenig, Julian [VerfasserIn]   i
 Herpertz, Sabine [VerfasserIn]   i
 Steinmann, Sylvia [VerfasserIn]   i
 Neukel, Corinne [VerfasserIn]   i
 Kilavuz, Pelin [VerfasserIn]   i
 Venne, Patrice van der [VerfasserIn]   i
 Bertsch, Katja [VerfasserIn]   i
 Kaess, Michael [VerfasserIn]   i
Titel:Adverse childhood experiences mediate the negative association between borderline personality disorder symptoms and plasma oxytocin
Verf.angabe:Emilia L. Mielke, Julian Koenig, Sabine C. Herpertz, Sylvia Steinmann, Corinne Neukel, Pelin Kilavuz, Patrice van der Venne, Katja Bertsch, Michael Kaess
E-Jahr:2023
Jahr:13 July 2023
Umfang:9 S.
Fussnoten:Gesehen am 18.01.2024
Titel Quelle:Enthalten in: Progress in neuro-psychopharmacology & biological psychiatry
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1982
Jahr Quelle:2023
Band/Heft Quelle:125(2023), Artikel-ID 110749, Seite 1-9
ISSN Quelle:1878-4216
Abstract:Background Interpersonal dysfunction is a core symptom of borderline personality disorder (BPD) and may be closely linked to adverse childhood experiences. According to a recent model on the pathology of BPD, the neuropeptide oxytocin might play an important role in the development and maintenance of the disorder. However, so far, only few studies with small adult samples have reported reduced baseline oxytocin levels in BPD that may be linked to adverse childhood experiences. Methods We examined baseline plasma oxytocin levels in 131 female patients with BPD and 124 non-BPD female controls across a large age span (12-50 years). Additionally, 113 female patients with less than five DSM-IV BPD features were included to examine the association between plasma oxytocin levels and the number of fulfilled BPD criteria. We also explored associations between plasma oxytocin and adverse childhood experiences as well as depressive symptoms in BPD. Results Patients with BPD had reduced plasma oxytocin levels compared to non-BPD controls and this was independent of age. Plasma oxytocin was negatively associated with the number of fulfilled BPD criteria. The exploratory regression model revealed no association between plasma oxytocin and depressive symptoms but an association between plasma oxytocin and adverse childhood experiences, which in fact mediated the relationship between BPD criteria und plasma oxytocin. Conclusion In a large sample of individuals with BPD across a large age span, our results replicate and extend previous reports of reduced plasma oxytocin levels that might be related to adverse childhood experiences thus providing further evidence for a prominent role of oxytocin in BPD.
DOI:doi:10.1016/j.pnpbp.2023.110749
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.pnpbp.2023.110749
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0278584623000350
 DOI: https://doi.org/10.1016/j.pnpbp.2023.110749
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adversity
 Depression
 Maltreatment
 Social cognition
 Trauma
K10plus-PPN:1878431579
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69162957   QR-Code
zum Seitenanfang