Status: Bibliographieeintrag
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| Verfasst von: | Ameline, Baptiste [VerfasserIn]  |
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| | Kovac, Michal [VerfasserIn] |
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| | Nathrath, Michaela [VerfasserIn] |
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| | Barenboim, Maxim [VerfasserIn] |
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| | Witt, Olaf [VerfasserIn] |
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| | Krieg, Andreas H. [VerfasserIn] |
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| | Baumhoer, Daniel [VerfasserIn] |
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| Titel: | Overactivation of the IGF signalling pathway in osteosarcoma |
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| Titelzusatz: | a potential therapeutic target? |
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| Verf.angabe: | Baptiste Ameline, Michal Kovac, Michaela Nathrath, Maxim Barenboim, Olaf Witt, Andreas H Krieg and Daniel Baumhoer |
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| E-Jahr: | 2021 |
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| Jahr: | March 2021 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 19.1.2024 |
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| Titel Quelle: | Enthalten in: The journal of pathology: clinical research |
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| Ort Quelle: | Chichester : Wiley, 2015 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 7(2021), 2 vom: März, Seite 165-172 |
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| ISSN Quelle: | 2056-4538 |
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| Abstract: | Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. More than a third of patients do not respond to standard therapy and urgently require alternative treatment options. Due to a high degree of inter- and intra-tumoural genomic heterogeneity and complexity, recurrent molecular alterations that could serve as prognostic predictors or therapeutic targets are still lacking in osteosarcoma. Copy number (CN) gains involving the IGF1R gene, however, have been suggested as a potential surrogate marker for treating a subset of patients with IGF1R inhibitors. In this study, we screened a large set of osteosarcomas and found specific CN gains of the IGF1R gene in 18 of 253 (7.1%) cases with corresponding IGF1R overexpression. Despite the discouraging results observed in clinical trials in other tumours so far, focusing only on selected patients with osteosarcoma that show evidence of IGF pathway activation might represent a promising new and innovative treatment approach. |
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| DOI: | doi:10.1002/cjp2.191 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/cjp2.191 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cjp2.191 |
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| | DOI: https://doi.org/10.1002/cjp2.191 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chromoanagenesis |
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| | IGF1R |
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| | osteosarcoma |
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| | targeted treatment |
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| K10plus-PPN: | 1878547062 |
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| Verknüpfungen: | → Zeitschrift |
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Overactivation of the IGF signalling pathway in osteosarcoma / Ameline, Baptiste [VerfasserIn]; March 2021 (Online-Ressource)
69163336
