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Verfasst von:Feilcke, Ruth [VerfasserIn]   i
 Bär, Volker [VerfasserIn]   i
 Wendt, Constanze [VerfasserIn]   i
 Imming, Peter [VerfasserIn]   i
Titel:Antibacterial and disinfecting effects of standardised tea extracts on more than 100 clinical isolates of methicillin-resistant Staphylococcus aureus
Verf.angabe:Ruth Feilcke, Volker Bär, Constanze Wendt and Peter Imming
E-Jahr:2023
Jahr:29 September 2023
Umfang:10 S.
Illustrationen:Diagramme, Illustrationen
Fussnoten:Gesehen am 19.01.2024
Titel Quelle:Enthalten in: Plants
Ort Quelle:Basel : MDPI, 2012
Jahr Quelle:2023
Band/Heft Quelle:12(2023), 19, Artikel-ID 3440, Seite 1-10
ISSN Quelle:2223-7747
Abstract:Methicillin-resistant Staphylococcus aureus (MRSA) infections are still a major problem in hospitals. The excellent safety profile, accessibility and anti-infective activity of tea extracts make them promising agents for the treatment of infected wounds. To investigate the possibility of sterilising MRSA-infected surfaces, including skin with tea extracts, we determined the MICs for different extracts from green and black tea (Camellia sinensis), including epigallocatechin gallate (EGCG), on a large number of clinical isolates of MRSA, selected to represent a high genetic diversity. The extracts were prepared to achieve the maximal extraction of EGCG from tea and were used as stable lyophilisate with a defined EGCG content. All extracts showed a complete inhibition of cell growth at a concentration of approx. 80 µg/mL of EGCG after a contact time of 24 h. Time-kill plots were recorded for the extract with the highest amount of EGCG. The reduction factor (RF) was 5 after a contact time of 240 min. EGCG and tea extracts showed an RF of 2 in methicillin-sensitive S. aureus. Extracts from green and black tea showed lower MICs than an aqueous solution with the same concentration of pure EGCG. To the best of our knowledge, we are the first to show a reduction of 99.999% of clinically isolated MRSA by green tea extract within 4 h.
DOI:doi:10.3390/plants12193440
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/plants12193440
 kostenfrei: Volltext: https://www.mdpi.com/2223-7747/12/19/3440
 kostenfrei: Resolving-System: https://doi.org/10.25673/113742
 DOI: https://doi.org/10.3390/plants12193440
 DOI: https://doi.org/10.25673/113742
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Camellia sinensis
 Staphylococcus
 multi-resistance
 tea extracts
 time-kill plot
K10plus-PPN:1878555413
Verknüpfungen:→ Zeitschrift

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