Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Reinhart, Walter H. [VerfasserIn]  |
| Goerre, Stefan [VerfasserIn]  |
| Bärtsch, Peter [VerfasserIn]  |
Titel: | Acetazolamide reduces the erythropoietin response to hypoxia at high altitude in humans |
Verf.angabe: | Walter H. Reinhart, Stefan Goerre, Peter Bärtsch |
Jahr: | 1994 |
Umfang: | 6 S. |
Fussnoten: | Elektronische Reproduktion der Druck-Ausgabe 12. April 2010 ; Gesehen am 22.01.2024 |
Titel Quelle: | Enthalten in: Wilderness & environmental medicine |
Ort Quelle: | Colorado Springs, Colo. : Wilderness Medical Society, 1990 |
Jahr Quelle: | 1994 |
Band/Heft Quelle: | 5(1994), 3, Seite 312-317 |
ISSN Quelle: | 1545-1534 |
Abstract: | Objective - Acetazolamide, a carbonic anhydrase inhibitor, is often used as a prophylactic drug for acute mountain sickness. It may interfere with erythropoietin production due to its action on ventilation and renal function. - Design - A randomized, double-blind, placebo-controlled trial with 2×250mg acetazolamide daily beginning one day before ascent from 590 m to 4559 m. - Setting - High-altitude research facilities at the Capanna Regina Margherita (Italy) at an altitude of 4559 m. - Participants - Eighteen healthy volunteers, aged 24-42 years. Main outcome measure: Plasma erythropoietin was measured by radioimmunoassay before and after the ascent. - Results - The increase of erythropoietin at high altitude was smaller in the acetazolamide group (increase by 10.8±7.8 U/L or 58%) than in the placebo group (increase by 22.7±13.8 U/L or 113%, p<.01). - Conclusion - Acetazolamide reduces the erythropoietin response to hypoxia in humans, which might also have therapeutic implications in conditions such as secondary polycythemia. |
DOI: | doi:10.1580/0953-9859-5.3.312 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1580/0953-9859-5.3.312 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S095398599471130X |
| DOI: https://doi.org/10.1580/0953-9859-5.3.312 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | acetazolamide |
| erythropoietin |
| high altitude |
K10plus-PPN: | 1878625535 |
Verknüpfungen: | → Zeitschrift |
Acetazolamide reduces the erythropoietin response to hypoxia at high altitude in humans / Reinhart, Walter H. [VerfasserIn]; 1994 (Online-Ressource)
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