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| Verfasst von: | Kinscherf, Ralf [VerfasserIn]  |
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| | Fischbach, Thomas [VerfasserIn] |
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| | Mihm, Sabine [VerfasserIn] |
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| | Roth, Steffen [VerfasserIn] |
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| | Hohenhaus-Sievert, Elke [VerfasserIn] |
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| | Weiss, Claus [VerfasserIn] |
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| | Edler, Lutz [VerfasserIn] |
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| | Bärtsch, Peter [VerfasserIn] |
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| | Dröge, Wulf [VerfasserIn] |
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| Titel: | Effect of glutathione depletion and oral N-acetyl-cysteine treatment on CD4+ and CD8+ cells |
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| Verf.angabe: | Ralf Kinscherf, Thomas Fischbach, Sabine Mihm, Steffen Roth, Elke Hohenhaus-Sievert, Claus Weiss, Lutz Edler, Peter Bärtsch, Wulf Dröge |
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| Jahr: | 1994 |
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| Umfang: | 4 S. |
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| Fussnoten: | Im Titel sind die Pluszeichen hochgestellt ; Gesehen am 22.01.2024 |
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| Titel Quelle: | Enthalten in: Federation of American Societies for Experimental BiologyThe FASEB journal |
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| Ort Quelle: | Hoboken, NJ : Wiley, 1987 |
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| Jahr Quelle: | 1994 |
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| Band/Heft Quelle: | 8(1994), 6, Seite 448-451 |
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| ISSN Quelle: | 1530-6860 |
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| Abstract: | HIV-infected individuals and SIV-infected rhesus macaques have, on the average, decreased plasma cysteine and cystine concentrations and decreased intracellular glutathione levels. We show that the cysteine supply and the intracellular glutathione levels have a strong influence on the T cell system, A study of healthy human subjects revealed that persons with intracellular glutathione levels of 20-30 nmol/mg protein had significantly higher numbers of CD4+ T cells than persons with either lower or higher glutathione levels. Persons who moved during a 4-weck observation period from the optimal to the suboptimal range (10-20 nmol/mg) experienced, on the average, a 30% decrease in CD4+ T cell numbers. This decrease was prevented by treatment with N-acetyl-cysteine (NAC). NAC caused this relative increase of CD4+ T cell numbers in spite of decreasing glutathione levels and not by increasing the glutathione level. Our studies suggest that the immune system may be exquisitely sensitive not only against a cysteine and glutathione deficiency but also against an excess of cysteine.—Kinscherf, R., Fischbach, T., Mihm, S., Roth, S., Hohenhaus-Sievert, E., Weiss, C., Edler, L., Bärtsch, P., Dröge, W. Effect of glutathione depletion and oral N-acetyl-cysteine treatment on CD4+ and CD8+ cells. FASEB J. 8: 448-451; 1994. |
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| DOI: | doi:10.1096/fasebj.8.6.7909525 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1096/fasebj.8.6.7909525 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.8.6.7909525 |
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| | DOI: https://doi.org/10.1096/fasebj.8.6.7909525 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | glutathione disulfide |
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| | lymphocytes |
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| | mononuclear cells |
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| K10plus-PPN: | 1878627333 |
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| Verknüpfungen: | → Zeitschrift |
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Effect of glutathione depletion and oral N-acetyl-cysteine treatment on CD4+ and CD8+ cells / Kinscherf, Ralf [VerfasserIn]; 1994 (Online-Ressource)
