Coagulation and thrombomodulin in response to exercise of different type and duration

• Verfasst von: Weiss, Claus [VerfasserIn]
• Verfasst von: Welsch, Bärbel [VerfasserIn]
• Verfasst von: Albert, Michael [VerfasserIn]
• Verfasst von: Friedmann-Bette, Birgit [VerfasserIn]
• Verfasst von: Strobel, Günther [VerfasserIn]
• Verfasst von: Jost, Joachim [VerfasserIn]
• Verfasst von: Nawroth, Peter Paul [VerfasserIn]
• Verfasst von: Bärtsch, Peter [VerfasserIn]
• Titel: Coagulation and thrombomodulin in response to exercise of different type and duration
• Verf.angabe: Claus Weiss, Bärbel Welsch, Michael Albert, Birgit Friedmann, Günther Strobel, Joachim Jost, Peter Nawroth, Peter Bärtsch
• Jahr: 1998
• Umfang: 6 S.
• Fussnoten: Gesehen am 23.01.2024
• Titel Quelle: Enthalten in: Medicine and science in sports and exercise
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 1969
• Jahr Quelle: 1998
• Band/Heft Quelle: 30(1998), 8, Seite 1205-1210
• ISSN Quelle: 1530-0315
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1878720910

Abstract

Coagulation and thrombomodulin in response to exercise of different type and duration. Med. Sci. Sports Exerc., Vol. 30, No. 8, pp. 1205-1210, 1998. - Purpose: - The present study was conducted to evaluate the role of the duration of exercise and the impact of the exercise type for exercise-induced activation of coagulation. - Methods: - Eleven male triathletes were subjected to stepwise maximal (17 min) and 1-h maximal exercise in swimming, cycling, and running. Changes of hemostatic variables and of plasma thrombomodulin, a marker of endothelial cell activation, were monitored. - Results: - Irrespective of the type of exercise, alterations in markers of thrombin (prothrombin fragment 1 + 2, thrombin-antithrombin III complexes) and fibrin formation (fibrinopeptide A) were more pronounced after 1-h exercise than after stepwise maximal exercise. Hemostatic parameters rose to the highest levels after running resulting in substantial fibrin formation as indicated by fibrinopeptide A increasing from 1.33 ng·mL−1 to 2.25 ng·mL−1 (P < 0.05) after 1-h exercise testing. Significant changes of plasma thrombomodulin were detected exclusively after running with increases from 38.2 ng·mL−1 to 44.2 ng·mL−1(1 h, P < 0.01). - Conclusions: - The data demonstrated that prolonged exercise is necessary for exercise-induced activation of coagulation resulting in thrombin and fibrin formation and suggested that endothelial cell activation possibly due to mechanical factors associated with running might play a role.