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| Verfasst von: | Kandala, Sridhar [VerfasserIn]  |
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| | Ramos, Maria [VerfasserIn] |
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| | Voith von Voithenberg, Lena [VerfasserIn] |
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| | Díaz-Jiménez, Alberto [VerfasserIn] |
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| | Chocarro, Sara [VerfasserIn] |
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| | Keding, Johanna [VerfasserIn] |
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| | Brors, Benedikt [VerfasserIn] |
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| | Imbusch, Charles [VerfasserIn] |
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| | Sotillo, Rocio [VerfasserIn] |
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| Titel: | Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer |
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| Verf.angabe: | Sridhar Kandala, Maria Ramos, Lena Voith von Voithenberg, Alberto Diaz-Jimenez, Sara Chocarro, Johanna Keding, Benedikt Brors, Charles D. Imbusch, and Rocio Sotillo |
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| E-Jahr: | 2023 |
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| Jahr: | 26 December 2023 |
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| Umfang: | 22 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 25.01.2024 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 42(2023), 12, Artikel-ID 113266, Seite 1-22 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Chromosome instability (CIN) contributes to resistance to therapies and tumor evolution. Although natural killer (NK) cells can eliminate cells with complex karyotypes, high-CIN human tumors have an immunosuppressive phenotype. To understand which CIN-associated molecular features alter immune recognition during tumor evolution, we overexpress Polo-like kinase 1 (Plk1) in a Her2+ breast cancer model. These high-CIN tumors activate a senescence-associated secretory phenotype (SASP), upregulate PD-L1 and CD206, and induce non-cell-autonomous nuclear factor κB (NF-κβ) signaling, facilitating immune evasion. Single-cell RNA sequencing from pre-neoplastic mammary glands unveiled the presence of Arg1+ macrophages, NK cells with reduced effector functions, and increased resting regulatory T cell infiltration. We further show that high PLK1-expressing human breast tumors display gene expression patterns associated with SASP, NF-κβ signaling, and immune suppression. These findings underscore the need to understand the immune landscape in CIN tumors to identify more effective therapies, potentially combining immune checkpoint or NF-κβ inhibitors with current treatments. |
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| DOI: | doi:10.1016/j.celrep.2023.113266 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.celrep.2023.113266 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S2211124723012780 |
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| | DOI: https://doi.org/10.1016/j.celrep.2023.113266 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chromosomal instability |
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| | Her2 breast cancer |
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| | immune evasion |
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| | NF-κβ signaling |
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| | senescence-associated secretory phenotype, SASP |
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| | single-cell sequencing |
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| K10plus-PPN: | 187897615X |
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| Verknüpfungen: | → Zeitschrift |
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Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer / Kandala, Sridhar [VerfasserIn]; 26 December 2023 (Online-Ressource)
