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| Verfasst von: | Ramesh, Vignesh [VerfasserIn]  |
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| | Gollavilli, Paradesi Naidu [VerfasserIn] |
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| | Pinna, Luisa [VerfasserIn] |
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| | Siddiqui, Mohammad Aarif [VerfasserIn] |
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| | Turtos, Adriana Martinez [VerfasserIn] |
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| | Napoli, Francesca [VerfasserIn] |
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| | Antonelli, Yasmin [VerfasserIn] |
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| | Leal-Egaña, Aldo [VerfasserIn] |
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| | Havelund, Jesper Foged [VerfasserIn] |
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| | Jakobsen, Simon Toftholm [VerfasserIn] |
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| | Boiteux, Elisa Le [VerfasserIn] |
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| | Volante, Marco [VerfasserIn] |
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| | Færgeman, Nils Joakim [VerfasserIn] |
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| | Jensen, Ole N [VerfasserIn] |
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| | Siersbæk, Rasmus [VerfasserIn] |
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| | Somyajit, Kumar [VerfasserIn] |
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| | Ceppi, Paolo [VerfasserIn] |
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| Titel: | Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma |
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| Verf.angabe: | Vignesh Ramesh, Paradesi Naidu Gollavilli, Luisa Pinna, Mohammad Aarif Siddiqui, Adriana Martinez Turtos, Francesca Napoli, Yasmin Antonelli, Aldo Leal‐Egaña, Jesper Foged Havelund, Simon Toftholm Jakobsen, Elisa Le Boiteux, Marco Volante, Nils Joakim Færgeman, Ole N Jensen, Rasmus Siersbæk, Kumar Somyajit & Paolo Ceppi |
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| E-Jahr: | 2023 |
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| Jahr: | 28 September 2023 |
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| Umfang: | 24 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 25.01.2024 |
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| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationEMBO molecular medicine |
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| Ort Quelle: | Weinheim : Wiley-VCH, 2009 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 15(2023), 12, Artikel-ID e17836, Seite 1-24 |
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| ISSN Quelle: | 1757-4684 |
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| Abstract: | The epithelial‐to‐mesenchymal transition (EMT) plays a central role in the development of cancer metastasis and resistance to chemotherapy. However, its pharmacological treatment remains challenging. Here, we used an EMT‐focused integrative functional genomic approach and identified an inverse association between short‐chain fatty acids (propionate and butanoate) and EMT in non‐small cell lung cancer (NSCLC) patients. Remarkably, treatment with propionate in vitro reinforced the epithelial transcriptional program promoting cell‐to‐cell contact and cell adhesion, while reducing the aggressive and chemo‐resistant EMT phenotype in lung cancer cell lines. Propionate treatment also decreased the metastatic potential and limited lymph node spread in both nude mice and a genetic NSCLC mouse model. Further analysis revealed that chromatin remodeling through H3K27 acetylation (mediated by p300) is the mechanism underlying the shift toward an epithelial state upon propionate treatment. The results suggest that propionate administration has therapeutic potential in reducing NSCLC aggressiveness and warrants further clinical testing. |
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| DOI: | doi:10.15252/emmm.202317836 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.15252/emmm.202317836 |
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| | kostenfrei: Volltext: https://www.embopress.org/doi/full/10.15252/emmm.202317836 |
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| | DOI: https://doi.org/10.15252/emmm.202317836 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | epithelial-mesenchymal transition |
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| | H3K27 acetylation |
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| | metabolic inhibitor |
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| | metastasis |
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| | propionate |
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| K10plus-PPN: | 1879008068 |
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| Verknüpfungen: | → Zeitschrift |
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Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma / Ramesh, Vignesh [VerfasserIn]; 28 September 2023 (Online-Ressource)
