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| Verfasst von: | Lin, Yanzhu [VerfasserIn]  |
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| | Gahn, Johannes [VerfasserIn] |
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| | Banerjee, Kuheli [VerfasserIn] |
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| | Dobreva, Gergana [VerfasserIn] |
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| | Singhal, Mahak [VerfasserIn] |
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| | Dubrac, Alexandre [VerfasserIn] |
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| | Ola, Roxana [VerfasserIn] |
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| Titel: | Role of endothelial PDGFB in arterio-venous malformations pathogenesis |
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| Verf.angabe: | Yanzhu Lin, Johannes Gahn, Kuheli Banerjee, Gergana Dobreva, Mahak Singhal, Alexandre Dubrac, Roxana Ola |
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| E-Jahr: | 2023 |
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| Jahr: | 09 December 2023 |
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| Umfang: | 17 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 26.01.2024 |
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| Titel Quelle: | Enthalten in: Angiogenesis |
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| Ort Quelle: | Dordrecht [u.a.] : Springer Science + Business Media B.V, 1997 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 27(2024), 2, Seite 193-209 |
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| ISSN Quelle: | 1573-7209 |
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| Abstract: | Arterial-venous malformations (AVMs) are direct connections between arteries and veins without an intervening capillary bed. Either familial inherited or sporadically occurring, localized pericytes (PCs) drop is among the AVMs’ hallmarks. Whether impaired PC coverage triggers AVMs or it is a secondary event is unclear. Here we evaluated the role of the master regulator of PC recruitment, Platelet derived growth factor B (PDGFB) in AVM pathogenesis. Using tamoxifen-inducible deletion of Pdgfb in endothelial cells (ECs), we show that disruption of EC Pdgfb-mediated PC recruitment and maintenance leads to capillary enlargement and organotypic AVM-like structures. These vascular lesions contain non-proliferative hyperplastic, hypertrophic and miss-oriented capillary ECs with an altered capillary EC fate identity. Mechanistically, we propose that PDGFB maintains capillary EC size and caliber to limit hemodynamic changes, thus restricting expression of Krüppel like factor 4 and activation of Bone morphogenic protein, Transforming growth factor β and NOTCH signaling in ECs. Furthermore, our study emphasizes that inducing or activating PDGFB signaling may be a viable therapeutic approach for treating vascular malformations. |
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| DOI: | doi:10.1007/s10456-023-09900-w |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1007/s10456-023-09900-w |
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| | kostenfrei: Volltext: https://link.springer.com/article/10.1007/s10456-023-09900-w |
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| | DOI: https://doi.org/10.1007/s10456-023-09900-w |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Arterial-venous zonation |
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| | AVMs |
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| | EC migration |
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| | PDGFB |
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| | Pericytes |
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| K10plus-PPN: | 1879064197 |
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| Verknüpfungen: | → Zeitschrift |
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Role of endothelial PDGFB in arterio-venous malformations pathogenesis / Lin, Yanzhu [VerfasserIn]; 09 December 2023 (Online-Ressource)
