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| Verfasst von: | Breyer, Johannes [VerfasserIn]  |
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| | Eckstein, Markus [VerfasserIn] |
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| | Sikic, Danijel [VerfasserIn] |
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| | Wezel, Felix [VerfasserIn] |
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| | Roghmann, Florian [VerfasserIn] |
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| | Brehmer, Mirco [VerfasserIn] |
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| | Wirtz, Ralph M. [VerfasserIn] |
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| | Jarczyk, Jonas [VerfasserIn] |
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| | Erben, Philipp [VerfasserIn] |
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| | Bahlinger, Veronika [VerfasserIn] |
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| | Goldschmidt, Franziska [VerfasserIn] |
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| | Fechner, Guido [VerfasserIn] |
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| | Chen, Jack [VerfasserIn] |
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| | Paxinos, Ellen [VerfasserIn] |
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| | Bates, Michael [VerfasserIn] |
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| | Haas, Maximilian [VerfasserIn] |
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| | Zengerling, Friedemann [VerfasserIn] |
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| | Bolenz, Christian [VerfasserIn] |
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| | Burger, Maximilian [VerfasserIn] |
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| | Hartmann, Arndt [VerfasserIn] |
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| | Kriegmair, Maximilian [VerfasserIn] |
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| Titel: | Xpert bladder cancer monitor to predict the need for a second TURB (MoniTURB trial) |
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| Verf.angabe: | Johannes Breyer, Markus Eckstein, Danijel Sikic, Felix Wezel, Florian Roghmann, Mirco Brehmer, Ralph M. Wirtz, Jonas Jarczyk, Philipp Erben, Veronika Bahlinger, Franziska Goldschmidt, Guido Fechner, Jack Chen, Ellen Paxinos, Michael Bates, Maximilian Haas, Friedemann Zengerling, Christian Bolenz, Maximilian Burger, Arndt Hartmann, Maximilian C. Kriegmair & BRIDGE Consortium e.V. |
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| E-Jahr: | 2023 |
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| Jahr: | 18 September 2023 |
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| Umfang: | 10 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 26.01.2024 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Springer Nature, 2011 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 13(2023), Artikel-ID 15437, Seite 1-10 |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | To determine whether Xpert bladder cancer monitor, a noninvasive PCR-based biomarker test, can predict the need for 2nd transurethral resection of the bladder (TURB) better than clinical assessment. Patients scheduled for TURB were prospectively screened. After initial TURB, patients were assigned to 2nd TURB or follow-up cystoscopy at 3 months (FU) by clinicians’ discretion. Central urine cytology and Xpert monitor tests were performed prior to the 1st TURB and 2nd TURB or FU, respectively. Statistical analysis to compare clinical assessment and Xpert monitor comprised sensitivity (SENS), specificity (SPEC), NPV and PPV. Of 756 screened patients, 171 were included (114 with 2nd TURB, 57 with FU). Residual tumors were detected in 34 patients who underwent 2nd TURB, and recurrent tumors were detected in 2 patients with FU. SENS and SPEC of Xpert monitor were 83.3% and 53.0%, respectively, PPV was 32.6% and NPV was 92.1%. Clinical risk assessment outperformed Xpert monitor. In patients with pTa disease at initial TURB, Xpert monitor revealed a NPV of 96%. Xpert monitor was not superior than clinical assessment in predicting the need for 2nd TURB. It might be an option to omit 2nd TURB for selected patients with pTa disease. |
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| DOI: | doi:10.1038/s41598-023-42088-z |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41598-023-42088-z |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41598-023-42088-z |
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| | DOI: https://doi.org/10.1038/s41598-023-42088-z |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Biomarkers |
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| | Bladder |
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| | Cancer |
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| | Diagnostic markers |
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| | Tumour biomarkers |
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| | Urological cancer |
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| | Urology |
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| K10plus-PPN: | 1879088371 |
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| Verknüpfungen: | → Zeitschrift |
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Xpert bladder cancer monitor to predict the need for a second TURB (MoniTURB trial) / Breyer, Johannes [VerfasserIn]; 18 September 2023 (Online-Ressource)
