| |  Online-Ressource |
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| Verfasst von: | Fritze, Stefan [VerfasserIn]  |
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| | Brandt, Geva A. [VerfasserIn] |
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| | Benedyk, Anastasia [VerfasserIn] |
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| | Moldavski, Alexander [VerfasserIn] |
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| | Geiger-Primo, Lena S. [VerfasserIn] |
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| | Andoh, Jamila [VerfasserIn] |
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| | Volkmer, Sebastian [VerfasserIn] |
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| | Braun, Urs [VerfasserIn] |
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| | Kubera, Katharina Maria [VerfasserIn] |
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| | Wolf, Robert Christian [VerfasserIn] |
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| | Goltz, Christoph von der [VerfasserIn] |
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| | Schwarz, Emanuel [VerfasserIn] |
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| | Meyer-Lindenberg, Andreas [VerfasserIn] |
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| | Tost, Heike [VerfasserIn] |
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| | Hirjak, Dusan [VerfasserIn] |
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| Titel: | Psychomotor slowing in schizophrenia is associated with cortical thinning of primary motor cortex |
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| Titelzusatz: | a three cohort structural magnetic resonance imaging study |
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| Verf.angabe: | Stefan Fritze, Geva A. Brandt, Anastasia Benedyk, Alexander Moldavski, Lena S. Geiger-Primo, Jamila Andoh, Sebastian Volkmer, Urs Braun, Katharina M. Kubera, Robert C. Wolf, Christoph von der Goltz, Emanuel Schwarz, Andreas Meyer-Lindenberg, Heike Tost, Dusan Hirjak |
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| E-Jahr: | 2023 |
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| Jahr: | December 2023 |
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| Umfang: | 14 S. |
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| Fussnoten: | Online verfügbar: 15. September 2023 ; Gesehen am 26.01.2024 |
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| Titel Quelle: | Enthalten in: European neuropsychopharmacology |
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| Ort Quelle: | Amsterdam : Elsevier, 1990 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 77(2023) vom: Dez., Seite 53-66 |
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| ISSN Quelle: | 1873-7862 |
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| Abstract: | Psychomotor slowing (PS) is characterized by slowed movements and lower activity levels. PS is frequently observed in schizophrenia (SZ) and distressing because it impairs performance of everyday tasks and social activities. Studying brain topography contributing to PS in SZ can help to understand the underlying neurobiological mechanisms as well as help to develop more effective treatments that specifically target affected brain areas. Here, we conducted structural magnetic resonance imaging (sMRI) of three independent cohorts of right-handed SZ patients (SZ#1: n = 72, SZ#2: n = 37, SZ#3: n = 25) and age, gender and education matched healthy controls (HC) (HC#1: n = 40, HC#2: n = 37, HC#3: n = 38). PS severity in the three SZ cohorts was determined using the Positive and Negative Syndrome Scale (PANSS) item #G7 (motor retardation) and Trail-Making-Test B (TMT-B). FreeSurfer v7.2 was used for automated parcellation and segmentation of cortical and subcortical regions. SZ#1 patients showed reduced cortical thickness in right precentral gyrus (M1; p = 0.04; Benjamini-Hochberg [BH] corr.). In SZ#1, cortical thinning in right M1 was associated with PANSS item #G7 (p = 0.04; BH corr.) and TMT-B performance (p = 0.002; BH corr.). In SZ#1, we found a significant correlation between PANSS item #G7 and TMT-B (p = 0.005, ρ=0.326). In conclusion, PANSS G#7 and TMT-B might have a surrogate value for predicting PS in SZ. Cortical thinning of M1 rather than alterations of subcortical structures may point towards cortical pathomechanism underlying PS in SZ. |
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| DOI: | doi:10.1016/j.euroneuro.2023.08.499 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.euroneuro.2023.08.499 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0924977X2300665X |
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| | DOI: https://doi.org/10.1016/j.euroneuro.2023.08.499 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cortical thickness |
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| | FreeSurfer |
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| | Primary motor cortex |
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| | Psychomotor slowing |
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| | Schizophrenia |
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| K10plus-PPN: | 1879293439 |
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| Verknüpfungen: | → Zeitschrift |
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Psychomotor slowing in schizophrenia is associated with cortical thinning of primary motor cortex / Fritze, Stefan [VerfasserIn]; December 2023 (Online-Ressource)
