| |  Online-Ressource |
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| Verfasst von: | Gruber, Tim [VerfasserIn]  |
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| | Lechner, Franziska [VerfasserIn] |
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| | Murat, Cahuê [VerfasserIn] |
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| | Contreras, Raian E. [VerfasserIn] |
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| | Sanchez-Quant, Eva [VerfasserIn] |
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| | Miok, Viktorian [VerfasserIn] |
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| | Makris, Konstantinos [VerfasserIn] |
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| | Le Thuc, Ophélia [VerfasserIn] |
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| | González-García, Ismael [VerfasserIn] |
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| | García-Clave, Elena [VerfasserIn] |
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| | Althammer, Ferdinand [VerfasserIn] |
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| | Krabichler, Quirin [VerfasserIn] |
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| | DeCamp, Lisa M. [VerfasserIn] |
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| | Jones, Russell G. [VerfasserIn] |
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| | Lutter, Dominik [VerfasserIn] |
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| | Williams, Rhiannan H. [VerfasserIn] |
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| | Pfluger, Paul T. [VerfasserIn] |
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| | Müller, Timo D. [VerfasserIn] |
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| | Woods, Stephen C. [VerfasserIn] |
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| | Pospisilik, John Andrew [VerfasserIn] |
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| | Martinez-Jimenez, Celia P. [VerfasserIn] |
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| | Tschöp, Matthias H. [VerfasserIn] |
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| | Grinevich, Valéry [VerfasserIn] |
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| | García-Cáceres, Cristina [VerfasserIn] |
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| Titel: | High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling |
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| Verf.angabe: | Tim Gruber, Franziska Lechner, Cahuê Murat, Raian E. Contreras, Eva Sanchez-Quant, Viktorian Miok, Konstantinos Makris, Ophélia Le Thuc, Ismael González-García, Elena García-Clave, Ferdinand Althammer, Quirin Krabichler, Lisa M. DeCamp, Russell G. Jones, Dominik Lutter, Rhiannan H. Williams, Paul T. Pfluger, Timo D. Müller, Stephen C. Woods, John Andrew Pospisilik, Celia P. Martinez-Jimenez, Matthias H. Tschöp, Valery Grinevich, and Cristina García-Cáceres |
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| E-Jahr: | 2023 |
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| Jahr: | 31 October 2023 |
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| Umfang: | 26 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar 31 October 2023, Version des Artikels 31 October 2023 ; Gesehen am 29.01.2024 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 42(2023), 10 vom: Okt., Artikel-ID 113305, Seite 1-26 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Oxytocin-expressing paraventricular hypothalamic neurons (PVNOT neurons) integrate afferent signals from the gut, including cholecystokinin (CCK), to adjust whole-body energy homeostasis. However, the molecular underpinnings by which PVNOT neurons orchestrate gut-to-brain feeding control remain unclear. Here, we show that mice undergoing selective ablation of PVNOT neurons fail to reduce food intake in response to CCK and develop hyperphagic obesity on a chow diet. Notably, exposing wild-type mice to a high-fat/high-sugar (HFHS) diet recapitulates this insensitivity toward CCK, which is linked to diet-induced transcriptional and electrophysiological aberrations specifically in PVNOT neurons. Restoring OT pathways in diet-induced obese (DIO) mice via chemogenetics or polypharmacology sufficiently re-establishes CCK’s anorexigenic effects. Last, by single-cell profiling, we identify a specialized PVNOT neuronal subpopulation with increased κ-opioid signaling under an HFHS diet, which restrains their CCK-evoked activation. In sum, we document a (patho)mechanism by which PVNOT signaling uncouples a gut-brain satiation pathway under obesogenic conditions. |
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| DOI: | doi:10.1016/j.celrep.2023.113305 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2023.113305 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124723013177 |
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| | DOI: https://doi.org/10.1016/j.celrep.2023.113305 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CCK |
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| | gut hormone |
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| | gut-brain axis |
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| | neuropeptide |
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| | NTS |
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| | obesity |
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| | opioids |
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| | oxytocin |
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| | paraventricular hypothalamic nucleus |
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| | PVN |
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| K10plus-PPN: | 1879387069 |
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| Verknüpfungen: | → Zeitschrift |
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High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling / Gruber, Tim [VerfasserIn]; 31 October 2023 (Online-Ressource)
