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| Verfasst von: | Qian, Xin [VerfasserIn]  |
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| | Klatt, Stephan [VerfasserIn] |
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| | Bennewitz, Katrin [VerfasserIn] |
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| | Wohlfart, David Philipp [VerfasserIn] |
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| | Lou, Bowen [VerfasserIn] |
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| | Meng, Ye [VerfasserIn] |
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| | Büttner, Michael [VerfasserIn] |
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| | Poschet, Gernot [VerfasserIn] |
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| | Morgenstern, Jakob [VerfasserIn] |
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| | Fleming, Thomas [VerfasserIn] |
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| | Sticht, Carsten [VerfasserIn] |
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| | Haußer-Siller, Ingrid [VerfasserIn] |
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| | Fleming, Ingrid [VerfasserIn] |
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| | Szendrödi, Julia [VerfasserIn] |
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| | Nawroth, Peter Paul [VerfasserIn] |
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| | Kroll, Jens [VerfasserIn] |
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| Titel: | Impaired Detoxification of Trans, Trans-2,4-Decadienal, an Oxidation Product from Omega-6 Fatty Acids, Alters Insulin Signaling, Gluconeogenesis and Promotes Microvascular Disease |
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| Verf.angabe: | Xin Qian, Stephan Klatt, Katrin Bennewitz, David Philipp Wohlfart, Bowen Lou, Ye Meng, Michael Buettner, Gernot Poschet, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Ingrid Fleming, Julia Szendroedi, Peter Paul Nawroth, and Jens Kroll |
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| E-Jahr: | 2024 |
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| Jahr: | January 26, 2024 |
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| Umfang: | 17 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 7. Dezember 2023 ; Gesehen am 29.01.2024 |
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| Titel Quelle: | Enthalten in: Advanced science |
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| Ort Quelle: | Weinheim : Wiley-VCH, 2014 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 11(2024), 4, Artikel-ID 2302325, Seite 1-17 |
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| ISSN Quelle: | 2198-3844 |
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| Abstract: | Omega-6 fatty acids are the primary polyunsaturated fatty acids in most Western diets, while their role in diabetes remains controversial. Exposure of omega-6 fatty acids to an oxidative environment results in the generation of a highly reactive carbonyl species known as trans, trans-2,4-decadienal (tt-DDE). The timely and efficient detoxification of this metabolite, which has actions comparable to other reactive carbonyl species, such as 4-hydroxynonenal, acrolein, acetaldehyde, and methylglyoxal, is essential for disease prevention. However, the detoxification mechanism for tt-DDE remains elusive. In this study, the enzyme Aldh9a1b is identified as having a key role in the detoxification of tt-DDE. Loss of Aldh9a1b increased tt-DDE levels and resulted in an abnormal retinal vasculature and glucose intolerance in aldh9a1b−/− zebrafish. Transcriptomic and metabolomic analyses revealed that tt-DDE and aldh9a1b deficiency in larval and adult zebrafish induced insulin resistance and impaired glucose homeostasis. Moreover, alterations in hyaloid vasculature is induced by aldh9a1b knockout or by tt-DDE treatment can be rescued by the insulin receptor sensitizers metformin and rosiglitazone. Collectively, these results demonstrated that tt-DDE is the substrate of Aldh9a1b which causes microvascular damage and impaired glucose metabolism through insulin resistance. |
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| DOI: | doi:10.1002/advs.202302325 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1002/advs.202302325 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202302325 |
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| | DOI: https://doi.org/10.1002/advs.202302325 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | 4-decadienal |
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| | Aldh9a1b |
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| | diabetic retinopathy |
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| | insulin resistance |
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| | omega-6 fatty acids |
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| | prediabetes |
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| | trans |
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| | trans-2 |
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| | zebrafish |
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| K10plus-PPN: | 1879451867 |
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| Verknüpfungen: | → Zeitschrift |
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Impaired Detoxification of Trans, Trans-2,4-Decadienal, an Oxidation Product from Omega-6 Fatty Acids, Alters Insulin Signaling, Gluconeogenesis and Promotes Microvascular Disease / Qian, Xin [VerfasserIn]; January 26, 2024 (Online-Ressource)
