Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Hirsch, Daniela [VerfasserIn]   i
 Hardt, Julia [VerfasserIn]   i
 Sauer, Christian [VerfasserIn]   i
 Heselmeyer-Hadded, Kerstin [VerfasserIn]   i
 Witt, Stephanie [VerfasserIn]   i
 Kienle, Peter [VerfasserIn]   i
 Ried-Güldenstubbe, Thomas [VerfasserIn]   i
 Gaiser, Timo [VerfasserIn]   i
Titel:Molecular characterization of ulcerative colitis-associated colorectal carcinomas
Verf.angabe:Daniela Hirsch, Julia Hardt, Christian Sauer, Kerstin Heselmeyer-Hadded, Stephanie H. Witt, Peter Kienle, Thomas Ried, Timo Gaiser
E-Jahr:2021
Jahr:June 2021
Umfang:14 S.
Fussnoten:Gesehen am 10.11.2023
Titel Quelle:Enthalten in: Modern pathology
Ort Quelle:London : Nature Publishing Group, 1988
Jahr Quelle:2021
Band/Heft Quelle:34(2021), 6, Seite 1153-1166
ISSN Quelle:1530-0285
Abstract:Patients with ulcerative colitis (UC) are at increased risk for developing colorectal cancer (CRC). In contrast to sporadic colorectal tumorigenesis, TP53 mutations occur early in the progression from inflamed colonic epithelium to dysplasia to CRC, and are sometimes readily detectable in inflamed, (yet) non-dysplastic mucosa. Here, we analyzed formalin-fixed paraffin-embedded tissue samples from 19 patients with long-standing UC (median 18 years, range 3 to 34) who had developed CRC as a consequence of chronic inflammation of the large bowel. We performed microsatellite instability testing, copy number analysis by array-based comparative genomic hybridization, mutation analysis by targeted next generation sequencing (48-gene panel) and TP53 immunostaining. The results were compared to The Cancer Genome Atlas (TCGA) data on sporadic CRC. All UC-CRC lesions in our cohort were microsatellite stable. Overall, genomic imbalances of UC-CRCs showed patterns of chromosomal aneuploidies characteristic for sporadic CRC with the exception of gains of chromosome arm 5p (12 of 23 UC-CRC, 52%), which are rare in sporadic CRCs from TCGA (21 of 144, 15%; FDR adjusted P = 0.006). UC-CRCs showed a predilection for TP53 alterations, which was the most frequently mutated gene in our cohort (20 of 23, 87%). Interestingly, spatially separated tumor lesions from individual patients tended to harbor distinct TP53 mutations. Similar to CRCs arising in a background of Crohn’s colitis, the genetic landscape of UC-CRCs was characterized by TP53 mutations and chromosomal aneuploidies including gains of chromosome arm 5p. Both alterations harbor the potential for early detection in precursor lesions, thus complementing morphologic diagnosis.
DOI:doi:10.1038/s41379-020-00722-5
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1038/s41379-020-00722-5
 Volltext: https://linkinghub.elsevier.com/retrieve/pii/S0893395222006056
 DOI: https://doi.org/10.1038/s41379-020-00722-5
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1870060725
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69167112   QR-Code
zum Seitenanfang