Cardiac beta1-adrenoceptor autoantibodies in human heart disease

• Verfasst von: Deubner, Nikolas Maximilian [VerfasserIn]
• Verfasst von: Berliner, Dominik [VerfasserIn]
• Verfasst von: Schlipp, Angela [VerfasserIn]
• Verfasst von: Gelbrich, Götz [VerfasserIn]
• Verfasst von: Caforio, Alida L. P. [VerfasserIn]
• Verfasst von: Felix, Stephan B. [VerfasserIn]
• Verfasst von: Fu, Michael [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Verfasst von: Angermann, Christiane E. [VerfasserIn]
• Verfasst von: Lohse, Martin J. [VerfasserIn]
• Verfasst von: Ertl, Georg [VerfasserIn]
• Verfasst von: Störk, Stefan [VerfasserIn]
• Verfasst von: Jahns, Roland [VerfasserIn]
• Titel: Cardiac beta1-adrenoceptor autoantibodies in human heart disease
• Titelzusatz: rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study
• Verf.angabe: Nikolas Deubner, Dominik Berliner, Angela Schlipp, Götz Gelbrich, Alida L.P. Caforio, Stephan B. Felix, Michael Fu, Hugo Katus, Christiane E. Angermann, Martin J. Lohse, Georg Ertl, Stefan Störk, and Roland Jahns on behalf of the ETiCS-Study Group
• Jahr: 2010
• Umfang: 10 S.
• Illustrationen: Illustrationen
• Fussnoten: Online publish-ahead-of-print 21 May 2010 ; Gesehen am 31.01.2024
• Titel Quelle: Enthalten in: European journal of heart failure
• Ort Quelle: Oxford : Wiley, 1999
• Jahr Quelle: 2010
• Band/Heft Quelle: 12(2010), 7 vom: Juli, Seite 753-762
• ISSN Quelle: 1879-0844
• DOI: doi:10.1093/eurjhf/hfq072
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Antibody Specificity
• Sach-SW: Autoantibodies
• Sach-SW: Autoimmunity
• Sach-SW: Cardiomyopathy, Dilated
• Sach-SW: Humans
• Sach-SW: Immunoassay
• Sach-SW: Multicenter Studies as Topic
• Sach-SW: Myocardial Infarction
• Sach-SW: Myocarditis
• Sach-SW: Myocardium
• Sach-SW: Patient Selection
• Sach-SW: Receptors, Adrenergic, beta-1
• Sach-SW: Research Design
• K10plus-PPN: 1879660210

Abstract

AIMS: Evidence for a pathophysiologic relevance of autoimmunity in human heart disease has substantially increased over the past years. Conformational autoantibodies stimulating the cardiac beta1-adrenoceptor (beta1-aabs) are considered of importance in heart failure development and clinical pilot studies have shown their prognostic significance in human 'idiopathic' cardiomyopathy. - METHODS: We recently developed a novel highly sensitive fluorescence-based functional assay to detect stimulating beta1-aabs. We will use this method to assess Etiology, Titre-Course, and effect on Survival (ETiCS) of beta1-aabs in a prospective multicentre study with serial follow-up of patients after a first acute myocarditis or myocardial infarction. Several European core laboratories will jointly study the hypothesis that both disorders may trigger autoimmune reactions leading to the generation of beta1-aabs and/or other heart-directed aabs. Further, sera from healthy controls and well-characterized patient cohorts with dilated, ischaemic, or hypertensive cardiomyopathy will be analysed retrospectively for beta1-aab prevalence, incidence, persistence, and/or clearance. - CONCLUSION: ETiCS is so far the largest clinical diagnostic study projected to address cardiac autoimmunity. It attempts to unravel the pathophysiology of cardiac autoantibody formation and persistence/clearance. ETiCS will enhance current knowledge on autoimmunity in human heart disease and promote endeavours to develop novel therapies targeting cardiac aabs.