Balanced activation of coagulation and fibrinolysis after a 2-h triathlon

• Verfasst von: Bärtsch, Peter [VerfasserIn]
• Verfasst von: Welsch, Bärbel [VerfasserIn]
• Verfasst von: Albert, Michael [VerfasserIn]
• Verfasst von: Friedmann-Bette, Birgit [VerfasserIn]
• Verfasst von: Levi, Marcel [VerfasserIn]
• Verfasst von: Kruithof, Egbert K. O. [VerfasserIn]
• Titel: Balanced activation of coagulation and fibrinolysis after a 2-h triathlon
• Verf.angabe: Peter Bärtsch, Bärbel Welsch, Michael Albert, Birgit Friedmann, Marcel Levi, Egbert K.O. Kruithof
• E-Jahr: 1995
• Jahr: November 1995
• Umfang: 6 S.
• Fussnoten: Gesehen am 05.02.2024
• Titel Quelle: Enthalten in: Medicine and science in sports and exercise
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 1969
• Jahr Quelle: 1995
• Band/Heft Quelle: 27(1995), 11 vom: Nov., Seite 1465-1470
• ISSN Quelle: 1530-0315
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1879983427

Abstract

To examine whether exercise-induced thrombin formation is accompanied by increased in vivo plasmin formation, we measured molecular markers and neoantigens of the hemostatic system in 10 male subjects (mean 29 yr, range 19-38) before, immediately after, and 2, 8, and 21 h after a triathlon lasting 128-163 min. Thrombin-antithrombin (TAT) complexes, fibrinopeptide A (FPA), and tissue plasminogen activator (t-PA) antigen were maximally increased immediately after exercise and decreased thereafter rapidly. Prothrombin fragment 1+2 (PTF1+2), fibrin degradation products (FbDP) and plasmin-antiplasmin (PAP) complexes rose to a similar extent 0 and 2 h after exercise and decreased thereafter. The maximal levels of PTF1 + 2, TAT, FPA, and FbDP were 1.5-, 2.1-, 1.8-, and 1.9-fold above baseline values, respectively, while t-PA antigen and PAP rose 9.9− and 10.6-fold above baseline, respectively. This investigation shows that strenuous prolonged exercise leads to a moderate activation of blood coagulation resulting in thrombin and fibrin formation which is accompanied by a greatly enhanced plasmin generation. It is concluded that the hemostatic system of healthy individuals is well kept in balance when stimulated by prolonged strenuous exercise.