Chronic kidney disease after partial nephrectomy in patients with preoperative inconspicuous renal function

• Verfasst von: Nientiedt, Malin [VerfasserIn]
• Verfasst von: Bertolo, Riccardo [VerfasserIn]
• Verfasst von: Campi, Riccardo [VerfasserIn]
• Verfasst von: Capitanio, Umberto [VerfasserIn]
• Verfasst von: Erdem, Selcuk [VerfasserIn]
• Verfasst von: Kara, Önder [VerfasserIn]
• Verfasst von: Klatte, Tobias [VerfasserIn]
• Verfasst von: Larcher, Alessandro [VerfasserIn]
• Verfasst von: Mir, Maria Carmen [VerfasserIn]
• Verfasst von: Ouzaid, Idir [VerfasserIn]
• Verfasst von: Roussel, Eduard [VerfasserIn]
• Verfasst von: Salagierski, Maciej [VerfasserIn]
• Verfasst von: Waldbillig, Frank [VerfasserIn]
• Verfasst von: Kriegmair, Maximilian [VerfasserIn]
• Titel: Chronic kidney disease after partial nephrectomy in patients with preoperative inconspicuous renal function
• Titelzusatz: curiosity or relevant issue?
• Verf.angabe: Malin Nientiedt, Riccardo Bertolo, Riccardo Campi, Umberto Capitanio, Selcuk Erdem, Önder Kara, Tobias Klatte, Alessandro Larcher, Maria Carmen Mir, Idir Ouzaid, Eduard Roussel, Maciej Salagierski, Frank Waldbillig, Maximillian Christian Kriegmair
• Jahr: 2020
• Umfang: 8 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 06.02.2024
• Titel Quelle: Enthalten in: Clinical genitourinary cancer
• Ort Quelle: Dallas, Tex. : CIG Media Group, 2005
• Jahr Quelle: 2020
• Band/Heft Quelle: 18(2020), 6 vom: Dez., Seite e754-e761
• ISSN Quelle: 1938-0682
• DOI: doi:10.1016/j.clgc.2020.05.007
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Estimated glomerular filtration rate
• Sach-SW: Kidney cancer
• Sach-SW: Renal failure
• Sach-SW: Renal neoplasm
• Sach-SW: Risk factors
• K10plus-PPN: 1880111268

Abstract

Background - Chronic kidney disease (CKD) is a severe long-term complication after partial nephrectomy (PN). Clinical and scientific focus lies on patients with impaired renal function at the time of surgery. Little data is available on patients with normal preoperative renal function (NPRF). - Patients and Methods - Patients who underwent PN with a preoperative estimated glomular filtration rate > 60 mL/min/1.73m2 were retrospectively examined at 8 European urologic centers. The occurrence of new onset CKD ≥ stage III after surgery (sCKD) was defined as the primary endpoint. Group comparisons and risk correlations were determined. Based on this data, a risk stratification model for sCKD was developed. - Results - Of the 1315 patients with NPRF included, 249 (18.9%) developed sCKD after a median follow-up of 44 months (range, 6-255 months). Pair analysis and univariable regression revealed age, arterial hypertension, American Society of Anesthesiologists score, tumor stage, surgical approach, intraoperative blood loss, perioperative blood transfusions and preoperative CKD stage as predictors for sCKD development. Multivariate analysis confirmed perioperative blood transfusion (hazard ratio [HR], 2.96; P ≤ .0001), age (≥ 55 years; HR, 2.60; P = .0002), tumor stage (> pT1; HR, 2.15; P = .025), and preoperative CKD stage (stage II vs. I; HR, 3.85; P ≤ .0001) as independent risk factors. A model that stratified patient risk for new onset CKD was highly significant (P < .0001). - Conclusion - Every fifth patient with NPRF developed sCKD following PN. Elderly patients with higher tumor stage and who require blood transfusion appear to be at increased risk. Based on our risk stratification, patients with ≥ 2 risk factors are candidates for an early, nephrologic follow-up.