Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Zielonka, Matthias [VerfasserIn]  |
| Xia, Jingjing [VerfasserIn]  |
| Friedel, Roland H. [VerfasserIn]  |
| Offermanns, Stefan [VerfasserIn]  |
| Worzfeld, Thomas [VerfasserIn]  |
Titel: | A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system |
Verf.angabe: | Matthias Zielonka, Jingjing Xia, Roland H. Friedel, Stefan Offermanns, Thomas Worzfeld |
E-Jahr: | 2010 |
Jahr: | 10 September 2010 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 09.02.2024 |
Titel Quelle: | Enthalten in: Experimental cell research |
Ort Quelle: | Orlando, Fla. : Academic Press, 1950 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 316(2010), 15 vom: Sept., Seite 2477-2486 |
ISSN Quelle: | 1090-2422 |
Abstract: | Plexins serve as receptors for semaphorins and play important roles in the developing nervous system. Plexin-B2 controls decisive developmental programs in the neural tube and cerebellum. However, whether Plexin-B2 also regulates biological functions in adult nonneuronal tissues is unknown. Here we show by two methodologically independent approaches that Plexin-B2 is expressed in discrete cell types of several nonneuronal tissues in the adult mouse. In the vasculature, Plexin-B2 is selectively expressed in functionally specialized endothelial cells. In endocrine organs, Plexin-B2 localizes to the pancreatic islets of Langerhans and to both cortex and medulla of the adrenal gland. Plexin-B2 expression is also detected in certain types of immune and epithelial cells. In addition, we report on a systematic comparison of the expression patterns of Plexin-B2 and its ligand Sema4C, which show complementarity or overlap in some but not all tissues. Furthermore, we demonstrate that Plexin-B2 and its family member Plexin-B1 display largely nonredundant expression patterns. This work establishes Plexin-B2 and Sema4C as potential regulators of the vascular and endocrine system and provides an anatomical basis to understand the biological functions of this ligand-receptor pair. |
DOI: | doi:10.1016/j.yexcr.2010.05.007 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.yexcr.2010.05.007 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S001448271000251X |
| DOI: https://doi.org/10.1016/j.yexcr.2010.05.007 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Plexin |
| Plexin-B1 |
| Plexin-B2 |
| Sema4C |
| Sema4D |
| Semaphorin |
K10plus-PPN: | 1880417340 |
Verknüpfungen: | → Zeitschrift |
¬A¬ systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system / Zielonka, Matthias [VerfasserIn]; 10 September 2010 (Online-Ressource)
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