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Verfasst von:Zielonka, Matthias [VerfasserIn]   i
 Xia, Jingjing [VerfasserIn]   i
 Friedel, Roland H. [VerfasserIn]   i
 Offermanns, Stefan [VerfasserIn]   i
 Worzfeld, Thomas [VerfasserIn]   i
Titel:A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system
Verf.angabe:Matthias Zielonka, Jingjing Xia, Roland H. Friedel, Stefan Offermanns, Thomas Worzfeld
E-Jahr:2010
Jahr:10 September 2010
Umfang:10 S.
Fussnoten:Gesehen am 09.02.2024
Titel Quelle:Enthalten in: Experimental cell research
Ort Quelle:Orlando, Fla. : Academic Press, 1950
Jahr Quelle:2010
Band/Heft Quelle:316(2010), 15 vom: Sept., Seite 2477-2486
ISSN Quelle:1090-2422
Abstract:Plexins serve as receptors for semaphorins and play important roles in the developing nervous system. Plexin-B2 controls decisive developmental programs in the neural tube and cerebellum. However, whether Plexin-B2 also regulates biological functions in adult nonneuronal tissues is unknown. Here we show by two methodologically independent approaches that Plexin-B2 is expressed in discrete cell types of several nonneuronal tissues in the adult mouse. In the vasculature, Plexin-B2 is selectively expressed in functionally specialized endothelial cells. In endocrine organs, Plexin-B2 localizes to the pancreatic islets of Langerhans and to both cortex and medulla of the adrenal gland. Plexin-B2 expression is also detected in certain types of immune and epithelial cells. In addition, we report on a systematic comparison of the expression patterns of Plexin-B2 and its ligand Sema4C, which show complementarity or overlap in some but not all tissues. Furthermore, we demonstrate that Plexin-B2 and its family member Plexin-B1 display largely nonredundant expression patterns. This work establishes Plexin-B2 and Sema4C as potential regulators of the vascular and endocrine system and provides an anatomical basis to understand the biological functions of this ligand-receptor pair.
DOI:doi:10.1016/j.yexcr.2010.05.007
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.yexcr.2010.05.007
 Volltext: https://www.sciencedirect.com/science/article/pii/S001448271000251X
 DOI: https://doi.org/10.1016/j.yexcr.2010.05.007
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Plexin
 Plexin-B1
 Plexin-B2
 Sema4C
 Sema4D
 Semaphorin
K10plus-PPN:1880417340
Verknüpfungen:→ Zeitschrift

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