A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system

• Verfasst von: Zielonka, Matthias [VerfasserIn]
• Verfasst von: Xia, Jingjing [VerfasserIn]
• Verfasst von: Friedel, Roland H. [VerfasserIn]
• Verfasst von: Offermanns, Stefan [VerfasserIn]
• Verfasst von: Worzfeld, Thomas [VerfasserIn]
• Titel: A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system
• Verf.angabe: Matthias Zielonka, Jingjing Xia, Roland H. Friedel, Stefan Offermanns, Thomas Worzfeld
• E-Jahr: 2010
• Jahr: 10 September 2010
• Umfang: 10 S.
• Fussnoten: Gesehen am 09.02.2024
• Titel Quelle: Enthalten in: Experimental cell research
• Ort Quelle: Orlando, Fla. : Academic Press, 1950
• Jahr Quelle: 2010
• Band/Heft Quelle: 316(2010), 15 vom: Sept., Seite 2477-2486
• ISSN Quelle: 1090-2422
• DOI: doi:10.1016/j.yexcr.2010.05.007
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Plexin
• Sach-SW: Plexin-B1
• Sach-SW: Plexin-B2
• Sach-SW: Sema4C
• Sach-SW: Sema4D
• Sach-SW: Semaphorin
• K10plus-PPN: 1880417340

Abstract

Plexins serve as receptors for semaphorins and play important roles in the developing nervous system. Plexin-B2 controls decisive developmental programs in the neural tube and cerebellum. However, whether Plexin-B2 also regulates biological functions in adult nonneuronal tissues is unknown. Here we show by two methodologically independent approaches that Plexin-B2 is expressed in discrete cell types of several nonneuronal tissues in the adult mouse. In the vasculature, Plexin-B2 is selectively expressed in functionally specialized endothelial cells. In endocrine organs, Plexin-B2 localizes to the pancreatic islets of Langerhans and to both cortex and medulla of the adrenal gland. Plexin-B2 expression is also detected in certain types of immune and epithelial cells. In addition, we report on a systematic comparison of the expression patterns of Plexin-B2 and its ligand Sema4C, which show complementarity or overlap in some but not all tissues. Furthermore, we demonstrate that Plexin-B2 and its family member Plexin-B1 display largely nonredundant expression patterns. This work establishes Plexin-B2 and Sema4C as potential regulators of the vascular and endocrine system and provides an anatomical basis to understand the biological functions of this ligand-receptor pair.