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Verfasst von:Zhou, Wei [VerfasserIn]   i
 Kallifatidis, Georgios [VerfasserIn]   i
 Baumann, Bernd [VerfasserIn]   i
 Rausch, Vanessa [VerfasserIn]   i
 Mattern, Jürgen [VerfasserIn]   i
 Gladkich, Jury [VerfasserIn]   i
 Giese, Nathalia [VerfasserIn]   i
 Moldenhauer, Gerhard [VerfasserIn]   i
 Wirth, Thomas [VerfasserIn]   i
 Büchler, Markus W. [VerfasserIn]   i
 Salnikov, Alexey V. [VerfasserIn]   i
 Herr, Ingrid [VerfasserIn]   i
Titel:Dietary polyphenol quercetin targets pancreatic cancer stem cells
Verf.angabe:Wei Zhou, Georgios Kallifatidis, Bernd Baumann, Vanessa Rausch, Jürgen Mattern, Jury Gladkich, Nathalia Giese, Gerhard Moldenhauer, Thomas Wirth, Markus W. Büchler, Alexei V. Salnikov, Ingrid Herr
E-Jahr:2010
Jahr:September 2010
Umfang:11 S.
Fussnoten:Gesehen am 09.02.2024
Titel Quelle:Enthalten in: International journal of oncology
Ort Quelle:Athens : Spandidos Publ., 2001
Jahr Quelle:2010
Band/Heft Quelle:37(2010), 3 vom: Sept., Seite 551-561
ISSN Quelle:1791-2423
Abstract:According to the cancer stem cell hypothesis the aggressive growth and early metastasis of pancreatic cancer may arise through dysregulation of self-renewal of stem cells in the tissue. Since recent data suggest targeting of cancer stem cells by some dietary agents we studied the effect of quercetin, a major polyphenol and flavonoid commonly detected in many fruits and vegetables. Using in vitro and in vivo models of pancreatic cancer stem cells we found quercetin-mediated reduction of self-renewal as measured by spheroid and colony formation. Quercetin diminished ALDH1 activity and reverted apoptosis resistance as detected by substrate assays, FACS and Western blot analysis. Importantly, combination of quercetin with sulforaphane, an isothiocyanate enriched in broccoli, had synergistic effects. Although quercetin led to enhanced binding of the survival factor NF-κB, co-incubation with sulforaphane completely eliminated this pro-proliferative feature. Moreover, quercetin prevented expression of proteins involved in the epithelial-mesenchymal transition, which was even stronger in presence of sulforaphane, suggesting the blockade of signaling involved in early metastasis. In vivo, quercetin inhibited growth of cancer stem cell-enriched xenografts associated with reduced proliferation, angiogenesis, cancer stem cell-marker expression and induction of apoptosis. Co-incubation with sulforaphane increased these effects and no pronounced toxicity on normal cells or mice was observed. Our data suggest that food ingredients complement each other in the elimination of cancer stem cell-characteristics. Since carcinogenesis is a complex process, combination of bioactive dietary agents with complementary activities may be most effective.
DOI:doi:10.3892/ijo_00000704
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3892/ijo_00000704
 Volltext: https://www.spandidos-publications.com/10.3892/ijo_00000704
 DOI: https://doi.org/10.3892/ijo_00000704
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1880451794
Verknüpfungen:→ Zeitschrift

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