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Status: Bibliographieeintrag

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Verfasst von:Dick, Oliver [VerfasserIn]   i
 Bading, Hilmar [VerfasserIn]   i
Titel:Synaptic activity and nuclear calcium signaling protect hippocampal neurons from death signal-associated nuclear translocation of FoxO3a induced by extrasynaptic N-methyl-D-aspartate receptors
Verf.angabe:Oliver Dick and Hilmar Bading
E-Jahr:2010
Jahr:19 April 2010
Umfang:8 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 12.02.2024
Titel Quelle:Enthalten in: The journal of biological chemistry
Ort Quelle:Bethesda, Md. : ASBMB Publications, 1905
Jahr Quelle:2010
Band/Heft Quelle:285(2010), 25 vom: Juni, Seite 19354-19361
ISSN Quelle:1083-351X
Abstract:Synaptic activity and the generation of nuclear calcium signals promote neuronal survival through a transcription-dependent process that is not fully understood. Here we show that one mechanism of activity-induced acquired neuroprotection involves the Forkhead transcription factor, FoxO3a, which is known to induce genomic death responses upon translocation from the cytosol to the nucleus. Depletion of endogenous FoxO3a using RNA interference renders hippocampal neurons more resistant to excitotoxic cell death. Using a FoxO3a-green fluorescent protein (GFP) fusion protein to monitor in real time the localization of FoxO3a in hippocampal neurons, we found that several cell death inducing stimuli, including the stimulation of extrasynaptic N-methyl-D-aspartate receptors, growth factor withdrawal, and oxygen-glucose deprivation, caused a swift translocation of FoxO3a-GFP from the cytosol to the cell nucleus. This translocation was inhibited in hippocampal neurons that had undergone prolonged periods of synaptic activity before exposure to cell death-inducing conditions. The activity-dependent protection from death signal-induced FoxO3a-GFP nuclear translocation required synaptic N-methyl-D-aspartate receptor activation and was dependent on nuclear calcium signaling and calcium/calmodulin-dependent protein kinase IV. The modulation of nucleo-cytoplasmic shuttling of FoxO3a may represent one mechanism through which nuclear calcium-induced genomic responses affect cell death processes.
DOI:doi:10.1074/jbc.M110.127654
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1074/jbc.M110.127654
 DOI: https://doi.org/10.1074/jbc.M110.127654
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Active Transport, Cell Nucleus
 Animals
 Calcium
 Calcium Signaling
 Calcium-Calmodulin-Dependent Protein Kinase Type 4
 Cell Nucleus
 Forkhead Box Protein O3
 Forkhead Transcription Factors
 Glucose
 Green Fluorescent Proteins
 Hippocampus
 Neurodegenerative Diseases
 Rats
 Rats, Sprague-Dawley
 Receptors, N-Methyl-D-Aspartate
 Synaptic Transmission
K10plus-PPN:1880515350
Verknüpfungen:→ Zeitschrift

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