TP53 codon 72 polymorphism and the risk of colorectal cancer in an Azerbaijani population

• Verfasst von: Yagublu, Vugar [VerfasserIn]
• Verfasst von: Bayramov, Bayram [VerfasserIn]
• Verfasst von: Yuce, Melek [VerfasserIn]
• Verfasst von: Aslanov, Hazi [VerfasserIn]
• Titel: TP53 codon 72 polymorphism and the risk of colorectal cancer in an Azerbaijani population
• Titelzusatz: gastrointestinal tract
• Verf.angabe: Vugar Yagublu, Bayram Bayramov, Melek Yuce, Hazi Aslanov
• E-Jahr: 2022
• Jahr: 01 June 2022
• Umfang: 6 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 12.02.2024
• Titel Quelle: Enthalten in: The Turkish journal of gastroenterology
• Ort Quelle: Ankara : Society, 1999
• Jahr Quelle: 2022
• Band/Heft Quelle: 33(2022), 6 vom: Juni, Seite 485-490
• ISSN Quelle: 2148-5607
• DOI: doi:10.5152/tjg.2022.21189
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1880581558

Abstract

Background: We aimed to evaluate the association between the TP53 Arg72Pro gene polymorphism and risk of colorectal cancer in an Azerbaijani population. Methods: A total of 141 patients with colorectal cancer and 150 gender- and age-matched controls were involved in the study. The genotypes of the TP53 gene Arg72Pro polymorphism were detected by polymerase chain reaction-based restriction fragment length polymorphism analysis. Results: We found that the heterozygous genotypes Arg/Pro (odds ratio, 1.128; 95% CI, 0.657-1.937) and mutant Pro/Pro (odds ratio, 1.274; 95% CI, 0.648-2.504) were more frequent in colorectal cancer patients compared to healthy controls. The frequency of the mutant Pro allele (odds ratio, 1.122; 95% CI, 0.809-1.554) was revealed in 47.5% of colorectal cancer patients and in 44.7% of healthy controls. There was no association observed between TP53 Arg72Pro polymorphism and risk of colorectal cancer in an Azerbaijani population (P > .05). Conclusion: Our findings indicate a lack of relationship between TP53 Arg72Pro polymorphism and risk of colorectal cancer. Furthermore, we have found no statistical differences in the frequency of genotype and allele by sex, age, histological grade, tumor stage, smoking status, and alcohol consumption in this study.