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Verfasst von:Aumüller, Philipp [VerfasserIn]   i
 Rothfuss, Andreas [VerfasserIn]   i
 Polednik, Martin [VerfasserIn]   i
 Abo-Madyan, Yasser [VerfasserIn]   i
 Ehmann, Michael [VerfasserIn]   i
 Giordano, Frank Anton [VerfasserIn]   i
 Clausen, Sven [VerfasserIn]   i
Titel:Multiple direction needle-path planning and inverse dose optimization for robotic low-dose rate brachytherapy
Verf.angabe:Philipp Aumüller, Andreas Rothfuss, Martin Polednik, Yasser Abo-Madyan, Michael Ehmann, Frank A. Giordano, Sven Clausen
E-Jahr:2022
Jahr:May 2022
Umfang:15 S.
Illustrationen:Illustrationen
Fussnoten:Online verfügbar: 7. August 2021, Artikelversion: 29. Mai 2022 ; Gesehen am 13.02.2024
Titel Quelle:Enthalten in: Zeitschrift für medizinische Physik
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1990
Jahr Quelle:2022
Band/Heft Quelle:32(2022), 2 vom: Mai, Seite 173-187
ISSN Quelle:1876-4436
Abstract:Purpose - Robotic systems to assist needle placements for low-dose rate brachytherapy enable conformal dose planning only restricted to path planning around risk structures. We report a treatment planning system (TPS) combining multiple direction needle-path planning with inverse dose optimization algorithms. - Methods - We investigated in a path planning algorithm to efficiently locate needle injection points reaching the target volume without puncturing risk structures. A candidate needle domain with all combinations of trajectories is used for the optimization process. We report a modular algorithm for inverse radiation plan optimization. The initial plan with V100>99% is generated by the “greedy optimizer”. The “remove-seed algorithm” reduces the number of seeds in the high dose regions. The “depth-optimizer” varies the insertion depth of the needles. The “coverage-optimizer” locates under-dosed areas in the target volume and supports them with an additional amount of seeds. The dose calculation algorithm is benchmarked on an image set of a phantom with a liver metastasis (prescription dose Dpr=100 Gy) and is re-planned in a commercial CE-marked TPS to compare the calculated dose grids using a global gamma analysis. The inverse optimizer is benchmarked by calculating 10 plans on the same phantom to investigate the stability and statistical variability of the dose parameters. - Results - The path planning algorithm efficiently removes 72.5% of all considered injection points. The candidate needle domain consists of combinations of 1971 tip points and 827 injection points. The global gamma analysis with gamma 1%=2.9 Gy, 1 mm showed a pass rate of 98.5%. The dose parameters were V100=99.1±0.3%, V150=76.4±2.5%, V200=44.5±5.5% and D90=125.9±3.6 Gy and 10.7±1.3 needles with 34.0±0.8 seeds were used. The median of the TPS total running time was 4.4minutes. - Conclusions - The TPS generates treatment plans with acceptable dose coverage in a reasonable amount of time. The gamma analysis shows good accordance to the commercial TPS. The TPS allows taking full advantage of robotic navigation tools to enable a new precise and safe method of minimally invasive low-dose-rate brachytherapy.
DOI:doi:10.1016/j.zemedi.2021.06.003
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.zemedi.2021.06.003
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0939388921000611
 DOI: https://doi.org/10.1016/j.zemedi.2021.06.003
Datenträger:Online-Ressource
Sprache:eng
Bibliogr. Hinweis:Errata: Aumüller, Philipp, 1989 - : Erratum to “Multiple direction needle-path planning and inverse dose optimization for robotic low-dose rate brachytherapy” [Z Med Phys 32 (2022) 173-187]
Sach-SW:Brachytherapy
 Inverse optimization
 LDR
 Path planning
 Robotic
 Seeds
K10plus-PPN:1880597012
Verknüpfungen:→ Zeitschrift

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